| Cytogenetic effects of acetaldehyde in lymphocytes of Germans and Japanese: SCE, clastogenic activity, and cell cycle delay. | |
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MedLine Citation:
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PMID: 6852826 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Acetaldehyde, the first metabolite of ethanol oxidation, caused a dose-dependent linear increase in the induction of sister chromatid exchanges in lymphocytes from both Germans and Japanese. Japanese, possessing only aldehyde dehydrogenase II isozyme (ALDH I deficient phenotype) and showing adverse effects after alcohol ingestion, did not differ in SCE rates from Germans and Japanese possessing isozymes I and II. At acetaldehyde concentrations above 360 microM, a significant chromosome breaking effect and a definite delay in cell cycle events, as evaluated by the BdUrd labeling technique, was registered in all individuals. Pyridoxal 5'-phosphate showed no protective effect against acetaldehyde-induced SCE formation in our system. A 24-h extension of the normal culture period revealed significantly higher rates of SCE at acetaldehyde doses above 360 microM. |
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Authors:
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J U Böhlke; S Singh; H W Goedde |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Human genetics Volume: 63 ISSN: 0340-6717 ISO Abbreviation: Hum. Genet. Publication Date: 1983 |
Date Detail:
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Created Date: 1983-07-29 Completed Date: 1983-07-29 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7613873 Medline TA: Hum Genet Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 285-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetaldehyde
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pharmacology* Alcohol Drinking Aldehyde Dehydrogenase Aldehyde Oxidoreductases / deficiency Cell Cycle / drug effects* Cells, Cultured Chromosomes / drug effects* Crossing Over, Genetic / drug effects* Dose-Response Relationship, Drug Germany Humans Japan Lymphocytes / ultrastructure Sister Chromatid Exchange / drug effects* |
| Chemical | |
Reg. No./Substance:
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75-07-0/Acetaldehyde; EC 1.2.-/Aldehyde Oxidoreductases; EC 1.2.1.3/Aldehyde Dehydrogenase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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