Document Detail


Cytogenetic divergence of the same blastic clone in transformed chronic granulocytic leukemia: no effect on morphologic and immunologic features.
MedLine Citation:
PMID:  10459347     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A 19-year-old man with Ph-positive chronic granulocytic leukemia developed lymphoblastic transformation. Cytogenetic evolution was observed, with an abnormal clone showing i(17q) together with the t(9;22). Chronic phase of the chronic granulocytic leukemia were re-established with systemic chemotherapy, which also led to disappearance of the clone with i(17q). However, the acute lymphoblastic leukemia relapsed after 6 weeks, with the emergence of a phenotypically and genetically identical but cytogenetically distinctive clone. Our findings suggest that cytogenetic evolution in transformed chronic granulocytic leukemia reflects only the instability of the blastic clones, and may not determine its phenotypic differentiation.
Authors:
K F Wong; C C So; Y L Kwong
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Cancer genetics and cytogenetics     Volume:  113     ISSN:  0165-4608     ISO Abbreviation:  Cancer Genet. Cytogenet.     Publication Date:  1999 Aug 
Date Detail:
Created Date:  1999-09-10     Completed Date:  1999-09-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7909240     Medline TA:  Cancer Genet Cytogenet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  54-7     Citation Subset:  IM    
Affiliation:
Department of Pathology, Queen Elizabeth Hospital, Hong Kong, People's Republic of China.
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MeSH Terms
Descriptor/Qualifier:
Adult
Blast Crisis / genetics
Chromosome Deletion*
Chromosomes, Human, Pair 1
Chromosomes, Human, Pair 17
Chromosomes, Human, Pair 3
Clone Cells
Humans
Karyotyping
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics*,  immunology*,  pathology*
Lymphocyte Activation / genetics*
Male
Recurrence
Translocation, Genetic*

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