Document Detail


Cytogenetic damage in exfoliated oral mucosal cells and circulating lymphocytes of patients suffering from precancerous oral lesions.
MedLine Citation:
PMID:  9020897     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
One hundred patients suffering from oral submucous fibrosis (OSF), oral leukoplakia (OL) and oral lichen planus (OLP) were studied for the cytogenetic damage in oral mucosal cells and in circulating lymphocytes along with their habit patterns. It was observed that OSF was largely associated with betel nut containing masticants while OL was associated with chewing or smoking habit. It was further observed that their exfoliated oral mucosal cells had significantly higher numbers of micronucleated (Mn) cells as compared to these of healthy normal subjects without any chewing or smoking habit. Similar cytogenetic damage in the form of increased sister chromatid exchanges (SCE) was observed in circulating lymphocytes indicating that the carcinogenic agents produce damage not only in target tissue but also in other host cells such as circulating lymphocytes.
Authors:
S S Desai; S D Ghaisas; S D Jakhi; S V Bhide
Related Documents :
17912427 - Overexpression of septin1: possible contribution to the development of oral cancer.
9335467 - An electron microscopic study of the parabronchial epithelium in the mature lung of fou...
8149487 - Co-expression of human cyp1a1 and a human analog of cytochrome p450-ef in response to 2...
7690007 - Squamous cell carcinomas. an immunohistochemical study of cytokeratins and involucrin i...
10534067 - Human periodontal ligament fibroblast behavior on chemically conditioned dentine: an in...
4034147 - Cell surface alterations in murine leukaemia p388 adriamycin-resistant cells: studies o...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer letters     Volume:  109     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  1996 Dec 
Date Detail:
Created Date:  1997-02-27     Completed Date:  1997-02-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  9-14     Citation Subset:  IM    
Affiliation:
Swami Prakashananda Ayurveda Research Centre, Juhu, Bombay, India.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Areca
DNA Damage
Female
Fibrosis / epidemiology,  pathology
Humans
India / epidemiology
Leukoplakia, Oral / epidemiology,  pathology
Lichen Planus / epidemiology,  pathology*
Lymphocytes / pathology
Male
Micronucleus Tests
Middle Aged
Mouth Diseases / epidemiology,  pathology
Mouth Mucosa / pathology
Mouth Neoplasms / epidemiology,  pathology*
Plants, Medicinal
Precancerous Conditions / epidemiology,  pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  K-ras codon 12 and 61 point mutations in bromodeoxyuridine- and N-nitrosomethylurea-induced rat rena...
Next Document:  In vitro evaluation of Taxol combined with radiations in human squamous cell carcinoma spheroids.