Document Detail

Cytogenetic damage in exfoliated oral mucosal cells and circulating lymphocytes of patients suffering from precancerous oral lesions.
MedLine Citation:
PMID:  9020897     Owner:  NLM     Status:  MEDLINE    
One hundred patients suffering from oral submucous fibrosis (OSF), oral leukoplakia (OL) and oral lichen planus (OLP) were studied for the cytogenetic damage in oral mucosal cells and in circulating lymphocytes along with their habit patterns. It was observed that OSF was largely associated with betel nut containing masticants while OL was associated with chewing or smoking habit. It was further observed that their exfoliated oral mucosal cells had significantly higher numbers of micronucleated (Mn) cells as compared to these of healthy normal subjects without any chewing or smoking habit. Similar cytogenetic damage in the form of increased sister chromatid exchanges (SCE) was observed in circulating lymphocytes indicating that the carcinogenic agents produce damage not only in target tissue but also in other host cells such as circulating lymphocytes.
S S Desai; S D Ghaisas; S D Jakhi; S V Bhide
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer letters     Volume:  109     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  1996 Dec 
Date Detail:
Created Date:  1997-02-27     Completed Date:  1997-02-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  9-14     Citation Subset:  IM    
Swami Prakashananda Ayurveda Research Centre, Juhu, Bombay, India.
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MeSH Terms
DNA Damage
Fibrosis / epidemiology,  pathology
India / epidemiology
Leukoplakia, Oral / epidemiology,  pathology
Lichen Planus / epidemiology,  pathology*
Lymphocytes / pathology
Micronucleus Tests
Middle Aged
Mouth Diseases / epidemiology,  pathology
Mouth Mucosa / pathology
Mouth Neoplasms / epidemiology,  pathology*
Plants, Medicinal
Precancerous Conditions / epidemiology,  pathology*

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