| Cytogenetic biodosimetry: what it is and how we do it. | |
MedLine Citation:
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PMID: 23535678 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Dicentric assay is the international gold standard for cytogenetic biodosimetry after radiation exposure, despite being very labour-intensive, time-consuming, and highly expertise-dependent. It involves the identification of centromeres and structure of solid-stained chromosomes and the enumeration of dicentric chromosomes in a large number of first-division metaphases of cultured T lymphocytes. The dicentric yield is used to estimate the radiation exposure dosage according to a statistically derived and predetermined dose-response curve. It can be used for population triage after large-scale accidental over-exposure to ionising radiation or with a view to making clinical decisions for individual patients receiving substantial radiation. In this report, we describe our experience in the establishment of a cytogenetic biodosimetry laboratory in Queen Elizabeth Hospital, Hong Kong. This was part of the contingency plan for emergency measures against radiation accidents at nuclear power stations. |
Authors:
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K F Wong; Lisa Lp Siu; E Ainsbury; J Moquet |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Hong Kong medical journal = Xianggang yi xue za zhi / Hong Kong Academy of Medicine Volume: 19 ISSN: 1024-2708 ISO Abbreviation: Hong Kong Med J Publication Date: 2013 Apr |
Date Detail:
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Created Date: 2013-03-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9512509 Medline TA: Hong Kong Med J Country: China |
Other Details:
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Languages: eng Pagination: 168-73 Citation Subset: IM |
Affiliation:
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Department of Pathology, Queen Elizabeth Hospital, Jordan, Hong Kong. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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