Document Detail

Cytogenetic analysis of a primary salivary gland myoepithelioma.
MedLine Citation:
PMID:  10459346     Owner:  NLM     Status:  MEDLINE    
Myoepithelioma, a rare benign salivary gland neoplasm, is a tumor composed entirely of myoepithelial cells. Unlike pleomorphic adenoma, these tumors lack any ductal epithelial differentiation, and manifest a minor stromal element. Previous cytogenetic and molecular genetic studies have mainly investigated pleomorphic adenomas and reported recurring specific chromosomal alterations at 8q12 and 12q13-q15 regions. The cell origin of these alterations, however, remains speculative. We report the cytogenetic analysis of a parotid myoepithelioma and discuss the putative origin for the cells with cytogenetic alterations. Our analysis shows 12q12 involved in a translocation with a previously unreported partner (1q), and nonrandom del(9)(q22.1q22.3) and del(13)(q12q22). Our results indicate that the myoepithelial cell is the source of those cells with chromosomal alterations, and that myoepithelioma shares 12q alterations reported in a subset of pleomorphic adenomas.
A K el-Naggar; M Lovell; D L Callender; N G Ordonez; A M Killary
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Cancer genetics and cytogenetics     Volume:  113     ISSN:  0165-4608     ISO Abbreviation:  Cancer Genet. Cytogenet.     Publication Date:  1999 Aug 
Date Detail:
Created Date:  1999-09-10     Completed Date:  1999-09-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7909240     Medline TA:  Cancer Genet Cytogenet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  49-53     Citation Subset:  IM    
Division of Pathology, University of Texas M. D. Anderson Cancer, Houston 77030, USA.
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MeSH Terms
Actins / analysis
Chromosomes, Human, Pair 1
Chromosomes, Human, Pair 12
Chromosomes, Human, Pair 13
Chromosomes, Human, Pair 9
Desmin / analysis
Flow Cytometry
Keratins / analysis
Middle Aged
Myoepithelioma / genetics*,  pathology
Salivary Gland Neoplasms / genetics*,  pathology
Translocation, Genetic*
Reg. No./Substance:
0/Actins; 0/Desmin; 68238-35-7/Keratins

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