| Cytogenetic analysis of human oocytes from fertile women. | |
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MedLine Citation:
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PMID: 1806569 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Several reports have shown a relatively high incidence of chromosome anomalies in human inseminated-unfertilized oocytes from infertile women. In the present study, cytogenetic analysis was attempted in 73 human oocytes from 17 fertile women in order to establish the incidence of chromosome anomalies in the fertile population and to compare this with the incidence in inseminated-unfertilized oocytes from infertile women. Of 56 oocytes that could be analysed, 42 oocytes were haploid, 12 were hypohaploid and two exhibited fragmented chromosomes. The low rate of chromosome anomalies (3.6%) found in this population suggests that there is natural selection at fertilization against diploid oocytes and oocytes with fragmented chromosomes. This result also questions the high incidence of chromosome anomalies found in previous reports using inseminated-unfertilized oocytes. |
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Authors:
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J J Tarín; E Gómez; M Sampaio; M Ruiz; J Remohí; A Pellicer |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Human reproduction (Oxford, England) Volume: 6 ISSN: 0268-1161 ISO Abbreviation: Hum. Reprod. Publication Date: 1991 Sep |
Date Detail:
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Created Date: 1992-05-14 Completed Date: 1992-05-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8701199 Medline TA: Hum Reprod Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1100-3 Citation Subset: IM |
Affiliation:
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Instituto Valenciano de Infertilidad, General Hospital, Valencia, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Chromosome Aberrations* Female Humans Oocytes / ultrastructure* Ploidies |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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