Document Detail

Cytogenetic abnormalities in follicular dendritic cell sarcoma: report of two cases and literature review.
MedLine Citation:
PMID:  23422480     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The identification of chromosomal abnormalities in many hematopoietic and mesenchymal neoplasms has contributed significantly to classification systems. Follicular dendritic cell (FDC) sarcoma is an intermediate-grade malignancy with morphological and immunophenotypic features of follicular dendritic cells. Available data on genetic changes in this neoplasm are limited, with only isolated case reports of cytogenetic abnormalities.
CASE REPORT: We reviewed histological, immunophenotypic and cytogenetic findings in two cases of FDC sarcoma. The two cases of FDC sarcoma, were observed in female patients, one was nodal and one extranodal and they exhibited relatively complex karyotypes, characterized by structural abnormalities and loss of multiple chromosomes. One patient had several disease recurrences. At the last follow-up both patients were alive with no residual disease.
CONCLUSION: The cytogenetic findings in these two cases, coupled with the few previously described abnormal karyotypes, suggest that FDC sarcoma is cytogenetically diverse.
Anamarija M Perry; Marilu Nelson; Warren G Sanger; Julia A Bridge; Timothy C Greiner
Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  In vivo (Athens, Greece)     Volume:  27     ISSN:  1791-7549     ISO Abbreviation:  In Vivo     Publication Date:    2013 Mar-Apr
Date Detail:
Created Date:  2013-02-20     Completed Date:  2013-08-22     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  8806809     Medline TA:  In Vivo     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  211-4     Citation Subset:  IM    
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MeSH Terms
Chromosome Aberrations*
Combined Modality Therapy
Dendritic Cell Sarcoma, Follicular / genetics*,  metabolism,  pathology,  therapy
Dendritic Cells, Follicular / metabolism,  pathology*
Disease-Free Survival
Lung Neoplasms / genetics,  metabolism,  secondary
Lymph Nodes / pathology*
Middle Aged
Neoplasm Recurrence, Local
Soft Tissue Neoplasms / genetics*,  pathology
Treatment Outcome
Tumor Markers, Biological / genetics,  metabolism
Reg. No./Substance:
0/Tumor Markers, Biological

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