Document Detail


Cytogenetic abnormalities in essential thrombocythemia at presentation and transformation.
MedLine Citation:
PMID:  19728024     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cytogenetic abnormalities in patients with essential thrombocythemia (ET) are infrequent. Their role in survival of patients and disease transformation is not extensively studied. We describe cytogenetic abnormalities in 172 patients with ET at a single institution. At presentation nine (5.2%) patients had cytogenetic abnormality and three (1.7%) additional patients acquired them during follow-up. Survival of patients with cytogenetic changes at presentation did not differ when compared to the patients with normal karyotype. The more common were abnormalities of chromosome 9 (n = 4), 20 (n = 2), 5 (n = 2), and complex abnormalities (n = 2). Forty-one patients (23.8%) had additional cytogenetic tests performed for monitoring purposes during follow-up. Five patients (2.9%) with normal karyotype transformed to myelofibrosis (MF) without developing new cytogenetic changes at transformation. Two patients (1.2%) with normal karyotypes at presentation transformed to myelodysplastic syndrome and acute myeloid leukemia, respectively. Both acquired complex cytogenetic changes at the time of transformation. There is no rationale for repeating cytogenetic tests in ET patients on follow up, unless blood cell count changes suggest possible transformation.
Authors:
Matjaz Sever; Hagop Kantarjian; Sherry Pierce; Nitin Jain; Zeev Estrov; Jorge Cortes; Srdan Verstovsek
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Publication Detail:
Type:  Journal Article     Date:  2009-08-29
Journal Detail:
Title:  International journal of hematology     Volume:  90     ISSN:  1865-3774     ISO Abbreviation:  Int. J. Hematol.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2010-01-21     Completed Date:  2010-04-08     Revised Date:  2014-10-30    
Medline Journal Info:
Nlm Unique ID:  9111627     Medline TA:  Int J Hematol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  522-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Blood Cell Count
Cell Transformation, Neoplastic / genetics*
Chromosome Aberrations
Cytogenetic Analysis
Female
Follow-Up Studies
Humans
Kaplan-Meier Estimate
Leukemia, Myeloid, Acute / blood,  genetics
Male
Middle Aged
Myelodysplastic Syndromes / blood,  genetics
Primary Myelofibrosis / blood,  genetics
Thrombocythemia, Essential / blood,  genetics*
Young Adult
Grant Support
ID/Acronym/Agency:
P30 CA016672/CA/NCI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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