Document Detail


Cytogenetic abnormalities in essential thrombocythemia: prevalence and prognostic significance.
MedLine Citation:
PMID:  19236446     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: In the current study we describe cytogenetic findings as well as clinical correlates and long-term prognostic relevance of abnormal cytogenetics at the time of diagnosis of essential thrombocythemia (ET).
PATIENTS AND METHODS: The study cohort consisted of a consecutive group of patients with ET who fulfilled the World Health Organization diagnostic criteria, and in whom cytogenetic analysis was performed at diagnosis.
RESULTS: A total of 402 patients were studied (median age, 56 yrs; median follow-up 70 months). The prevalence of abnormal cytogenetics at diagnosis was 7% (28 of 402). The most common cytogenetic anomalies were trisomy 9 (four patients), abnormal chromosome 1 (three patients) and trisomy 8 (two patients). Parameters at diagnosis that were significantly associated with abnormal cytogenetics included palpable splenomegaly (P = 0.03), current tobacco use (P = 0.04); venous thrombosis (P = 0.02), and anemia with a hemoglobin of <10 g/dL (P = 0.02); but did not include JAK2V617F mutation status, or advanced age. During follow up, patients with abnormal cytogenetics did not have shorter survival, or increased transformation to acute leukemia or myelofibrosis.
CONCLUSION: Cytogenetic anomalies at diagnosis are relatively uncommon in ET, and do not predict evolution into more aggressive myeloid disorders, or inferior survival.
Authors:
Naseema Gangat; Ayalew Tefferi; Gita Thanarajasingam; Mrinal Patnaik; Susan Schwager; Rhett Ketterling; Alexandra P Wolanskyj
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Publication Detail:
Type:  Journal Article     Date:  2009-02-19
Journal Detail:
Title:  European journal of haematology     Volume:  83     ISSN:  1600-0609     ISO Abbreviation:  Eur. J. Haematol.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-22     Completed Date:  2009-07-02     Revised Date:  2012-06-05    
Medline Journal Info:
Nlm Unique ID:  8703985     Medline TA:  Eur J Haematol     Country:  England    
Other Details:
Languages:  eng     Pagination:  17-21     Citation Subset:  IM    
Affiliation:
Division of Hematology, Mayo Clinic, Rochester, MN, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Child
Child, Preschool
Chromosome Aberrations*
Chromosomes, Human, Pair 1 / genetics
Chromosomes, Human, Pair 8 / genetics
Chromosomes, Human, Pair 9 / genetics
Cohort Studies
Female
Humans
Janus Kinase 2 / genetics
Karyotyping
Leukemia, Myeloid, Acute / etiology,  genetics
Male
Middle Aged
Mutation
Primary Myelofibrosis / etiology,  genetics
Prognosis
Thrombocythemia, Essential / complications,  genetics*
Trisomy
Young Adult
Chemical
Reg. No./Substance:
EC 2.7.10.1/Janus Kinase 2; EC 2.7.10.2/JAK2 protein, human

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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