| Cytogenetic abnormalities in essential thrombocythemia: prevalence and prognostic significance. | |
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MedLine Citation:
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PMID: 19236446 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: In the current study we describe cytogenetic findings as well as clinical correlates and long-term prognostic relevance of abnormal cytogenetics at the time of diagnosis of essential thrombocythemia (ET). PATIENTS AND METHODS: The study cohort consisted of a consecutive group of patients with ET who fulfilled the World Health Organization diagnostic criteria, and in whom cytogenetic analysis was performed at diagnosis. RESULTS: A total of 402 patients were studied (median age, 56 yrs; median follow-up 70 months). The prevalence of abnormal cytogenetics at diagnosis was 7% (28 of 402). The most common cytogenetic anomalies were trisomy 9 (four patients), abnormal chromosome 1 (three patients) and trisomy 8 (two patients). Parameters at diagnosis that were significantly associated with abnormal cytogenetics included palpable splenomegaly (P = 0.03), current tobacco use (P = 0.04); venous thrombosis (P = 0.02), and anemia with a hemoglobin of <10 g/dL (P = 0.02); but did not include JAK2V617F mutation status, or advanced age. During follow up, patients with abnormal cytogenetics did not have shorter survival, or increased transformation to acute leukemia or myelofibrosis. CONCLUSION: Cytogenetic anomalies at diagnosis are relatively uncommon in ET, and do not predict evolution into more aggressive myeloid disorders, or inferior survival. |
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Authors:
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Naseema Gangat; Ayalew Tefferi; Gita Thanarajasingam; Mrinal Patnaik; Susan Schwager; Rhett Ketterling; Alexandra P Wolanskyj |
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Publication Detail:
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Type: Journal Article Date: 2009-02-19 |
Journal Detail:
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Title: European journal of haematology Volume: 83 ISSN: 1600-0609 ISO Abbreviation: Eur. J. Haematol. Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-06-22 Completed Date: 2009-07-02 Revised Date: 2012-06-05 |
Medline Journal Info:
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Nlm Unique ID: 8703985 Medline TA: Eur J Haematol Country: England |
Other Details:
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Languages: eng Pagination: 17-21 Citation Subset: IM |
Affiliation:
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Division of Hematology, Mayo Clinic, Rochester, MN, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Child Child, Preschool Chromosome Aberrations* Chromosomes, Human, Pair 1 / genetics Chromosomes, Human, Pair 8 / genetics Chromosomes, Human, Pair 9 / genetics Cohort Studies Female Humans Janus Kinase 2 / genetics Karyotyping Leukemia, Myeloid, Acute / etiology, genetics Male Middle Aged Mutation Primary Myelofibrosis / etiology, genetics Prognosis Thrombocythemia, Essential / complications, genetics* Trisomy Young Adult |
| Chemical | |
Reg. No./Substance:
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EC 2.7.10.1/Janus Kinase 2; EC 2.7.10.2/JAK2 protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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