Document Detail

Cytocompatibility of bio-inspired silicon carbide ceramics.
MedLine Citation:
PMID:  20737554     Owner:  NLM     Status:  MEDLINE    
Due to its good mechanical and biochemical properties and, also, because of its unique interconnected porosity, bio-inspired silicon carbide (bioSiC) can be considered as a promising material for biomedical applications, including controlled drug delivery devices and tissue engineering scaffolds. This innovative material is produced by molten-Si infiltration of carbon templates, obtained by controlled pyrolysis of vegetable precursors. The final SiC ceramic presents a porous-interconnected microstructure that mimics the natural hierarchical structure of bone tissue and allows the internal growth of tissue, as well as favors angiogenesis. In the present work, the in vitro cytocompatibility of the bio-inspired SiC ceramics obtained, in this case, from the tree sapelli (Entandrophragma cylindricum) was evaluated. The attachment, spreading, cytoskeleton organization, proliferation, and mineralization of the preosteoblastic cell line MC3T3-E1 were analyzed for up to 28 days of incubation by scanning electron microscopy, interferometric profilometry, confocal laser scanning microscopy, MTT assay, as well as red alizarin staining and quantification. Cells seeded onto these ceramics were able to attach, spread, and proliferate properly with the maintenance of the typical preosteoblastic morphology throughout the time of culture. A certain level of mineralization on the surface of the sapelli-based SiC ceramics is observed. These results demonstrated the cytocompatibility of this porous and hierarchical material.
M López-Alvarez; A de Carlos; P González; J Serra; B León
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of biomedical materials research. Part B, Applied biomaterials     Volume:  95     ISSN:  1552-4981     ISO Abbreviation:  J. Biomed. Mater. Res. Part B Appl. Biomater.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-13     Completed Date:  2011-01-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101234238     Medline TA:  J Biomed Mater Res B Appl Biomater     Country:  United States    
Other Details:
Languages:  eng     Pagination:  177-83     Citation Subset:  IM    
Applied Physics Department, University of Vigo, Campus Lagoas-Marcosende, 36310 Vigo, Spain.
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MeSH Terms
Biocompatible Materials / chemistry
Carbon Compounds, Inorganic / pharmacology,  therapeutic use*
Cell Adhesion
Cell Culture Techniques
Cell Line
Cell Proliferation
Ceramics / chemistry*
Osteoblasts / cytology*
Silicon Compounds / pharmacology,  therapeutic use*
Reg. No./Substance:
0/Biocompatible Materials; 0/Carbon Compounds, Inorganic; 0/Ceramics; 0/Silicon Compounds; 409-21-2/silicon carbide

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