Document Detail


Cytocompatibility of bio-inspired silicon carbide ceramics.
MedLine Citation:
PMID:  20737554     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Due to its good mechanical and biochemical properties and, also, because of its unique interconnected porosity, bio-inspired silicon carbide (bioSiC) can be considered as a promising material for biomedical applications, including controlled drug delivery devices and tissue engineering scaffolds. This innovative material is produced by molten-Si infiltration of carbon templates, obtained by controlled pyrolysis of vegetable precursors. The final SiC ceramic presents a porous-interconnected microstructure that mimics the natural hierarchical structure of bone tissue and allows the internal growth of tissue, as well as favors angiogenesis. In the present work, the in vitro cytocompatibility of the bio-inspired SiC ceramics obtained, in this case, from the tree sapelli (Entandrophragma cylindricum) was evaluated. The attachment, spreading, cytoskeleton organization, proliferation, and mineralization of the preosteoblastic cell line MC3T3-E1 were analyzed for up to 28 days of incubation by scanning electron microscopy, interferometric profilometry, confocal laser scanning microscopy, MTT assay, as well as red alizarin staining and quantification. Cells seeded onto these ceramics were able to attach, spread, and proliferate properly with the maintenance of the typical preosteoblastic morphology throughout the time of culture. A certain level of mineralization on the surface of the sapelli-based SiC ceramics is observed. These results demonstrated the cytocompatibility of this porous and hierarchical material.
Authors:
M López-Alvarez; A de Carlos; P González; J Serra; B León
Related Documents :
17323154 - Effect of multiple unconfined compression on cellular dense collagen scaffolds for bone...
17655274 - Evaluating drug efficacy and toxicology in three dimensions: using synthetic extracellu...
12568954 - The effect of selected growth factors on human anterior cruciate ligament cell interact...
16463084 - Development of ligament-like structural organization and properties in cell-seeded coll...
7963734 - Diagnosis of chlamydia trachomatis urethral infection in symptomatic and asymptomatic m...
6188644 - Axonal transport of noradrenaline, protein and glycoprotein in cat hypogastric nerves i...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of biomedical materials research. Part B, Applied biomaterials     Volume:  95     ISSN:  1552-4981     ISO Abbreviation:  J. Biomed. Mater. Res. Part B Appl. Biomater.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-13     Completed Date:  2011-01-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101234238     Medline TA:  J Biomed Mater Res B Appl Biomater     Country:  United States    
Other Details:
Languages:  eng     Pagination:  177-83     Citation Subset:  IM    
Affiliation:
Applied Physics Department, University of Vigo, Campus Lagoas-Marcosende, 36310 Vigo, Spain. miriammsd@uvigo.es
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Biocompatible Materials / chemistry
Carbon Compounds, Inorganic / pharmacology,  therapeutic use*
Cell Adhesion
Cell Culture Techniques
Cell Line
Cell Proliferation
Ceramics / chemistry*
Mice
Osteoblasts / cytology*
Porosity
Silicon Compounds / pharmacology,  therapeutic use*
Chemical
Reg. No./Substance:
0/Biocompatible Materials; 0/Carbon Compounds, Inorganic; 0/Ceramics; 0/Silicon Compounds; 409-21-2/silicon carbide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Compound muscle action potential and motor function in children with spinal muscular atrophy.
Next Document:  Characteristics and biocompatibility of a biodegradable genipin-cross-linked gelatin/?-tricalcium ph...