Document Detail

Cytochrome oxidase inhibition: a novel animal model of Alzheimer's disease.
MedLine Citation:
PMID:  1317179     Owner:  NLM     Status:  MEDLINE    
A profound decrease in activity of the mitochondrial enzyme cytochrome oxidase in blood platelets is a recently identified concomitant of Alzheimer's disease (AD). We investigated a possible pathogenic link between this finding and the symptoms of AD by mimicking this mitochondrial enzyme deficiency in rats. Rats were infused chronically with a selective inhibitor of cytochrome oxidase, sodium azide, or with saline delivered via subcutaneously implanted osmotic minipumps. The azide treatment impaired both spatial and nonspatial learning. Further, the azide treatment inhibited a low-threshold form of hippocampal long-term potentiation, primed burst potentiation. The behavioral deficits were not secondary to a sensory or motor impairment. Thus, chronic azide treatment of rats models some characteristics of AD.
M C Bennett; D M Diamond; S L Stryker; J K Parks; W D Parker
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of geriatric psychiatry and neurology     Volume:  5     ISSN:  0891-9887     ISO Abbreviation:  J Geriatr Psychiatry Neurol     Publication Date:    1992 Apr-Jun
Date Detail:
Created Date:  1992-07-01     Completed Date:  1992-07-01     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8805645     Medline TA:  J Geriatr Psychiatry Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  93-101     Citation Subset:  IM    
Department of Pharmacology, University of Colorado Health Sciences Center, Denver 80262.
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MeSH Terms
Alzheimer Disease / chemically induced*,  physiopathology
Arousal / drug effects,  physiology
Avoidance Learning / drug effects,  physiology
Azides / pharmacology*
Discrimination Learning / drug effects,  physiology
Disease Models, Animal*
Electron Transport Complex IV / antagonists & inhibitors*,  physiology
Hippocampus / drug effects,  physiopathology
Mental Recall / drug effects,  physiology
Mitochondria / drug effects,  physiology
Motor Activity / drug effects,  physiology
Neuronal Plasticity / drug effects,  physiology
Orientation / drug effects,  physiology
Rats, Inbred Strains
Reaction Time / drug effects,  physiology
Retention (Psychology) / drug effects,  physiology
Sodium Azide
Grant Support
Reg. No./Substance:
0/Azides; 26628-22-8/Sodium Azide; EC Transport Complex IV

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