| Cytochrome c Trp65→Ser substitution results in inhibition of acetic acid-induced programmed cell death in Saccharomyces cerevisiae. | |
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MedLine Citation:
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PMID: 21907312 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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To gain further insight into the role of cytochrome c (cyt c) in yeast programmed cell death induced by acetic acid (AA-PCD), comparison was made between wild type and two mutant cells, one lacking cyt c and the other (W65Scyc1) expressing a mutant iso-1-cyt c in a form unable to reduce cyt c oxidase, with respect to occurrence of AA-PCD, cyt c release, ROS production and caspase-like activity. We show that in W65Scyc1 cells: i. no release of mutant cyt c occurs with inhibition of AA-PCD shown to be independent on impairment of electron flow, ii. there is a decrease in ROS production and an increase in caspase-like activity. We conclude that cyt c release does not depend on cyt c function as an electron carrier and that when still associated to the mitochondrial membrane, cyt c in its reduced form has a role in AA-PCD, by regulating ROS production and caspase-like activity increase. |
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Authors:
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Nicoletta Guaragnella; Salvatore Passarella; Ersilia Marra; Sergio Giannattasio |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-2 |
Journal Detail:
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Title: Mitochondrion Volume: - ISSN: 1872-8278 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100968751 Medline TA: Mitochondrion Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier B.V. |
Affiliation:
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CNR, Istituto di Biomembrane e Bioenergetica, I-70126 Bari, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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