| Cytochrome b pseudogene originated from a highly divergent mitochondrial lineage in genus Rupicapra. | |
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MedLine Citation:
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PMID: 17416931 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have identified a nuclear pseudogene (numt) of cytochrome b (cytb) in chamois. The comparison of a fragment of 402 nucleotides of cytb and the pseudogene between the 2 species Rupicapra rupicapra and Rupicapra pyrenaica allowed direct measurement of relative rates and patterns of evolution. Mitochondrial genes evolved 7 to 12 times faster than their nuclear counterparts. Substitutions in the nucleus include a frameshift and a stop codon. Phylogenetic analysis of nuclear and mitochondrial lineages on Rupicapra and related species showed that the nuclear branch evolved as a functional mitochondrial gene until the split of the 2 species of chamois and as a typical pseudogene later on. We propose that the pseudogene originated from a highly divergent mitochondrial lineage that did not persist in the mitochondrion and transposed to the nucleus in a time close to speciation. The concurrence of highly differentiated lineages at speciation points to hybridization between highly divergent populations. |
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Authors:
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Fernando Rodríguez; Jesús Albornoz; Ana Domínguez |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-04-08 |
Journal Detail:
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Title: The Journal of heredity Volume: 98 ISSN: 0022-1503 ISO Abbreviation: J. Hered. Publication Date: 2007 May-Jun |
Date Detail:
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Created Date: 2007-06-20 Completed Date: 2007-09-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375373 Medline TA: J Hered Country: United States |
Other Details:
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Languages: eng Pagination: 243-9 Citation Subset: IM |
Affiliation:
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the Departamento de Biología Funcional, Area de Genética, Universidad de Oviedo, 33071 Oviedo, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Base Sequence Cytochromes b / genetics* DNA Primers DNA, Mitochondrial / genetics* Molecular Sequence Data Phylogeny Pseudogenes* Rupicapra / classification, genetics* Sequence Homology, Nucleic Acid |
| Chemical | |
Reg. No./Substance:
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0/DNA Primers; 0/DNA, Mitochondrial; 9035-37-4/Cytochromes b |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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