| Cytochrome P450IA1 polymorphisms along with PM(10) exposure contribute to the risk of birth weight reduction. | |
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MedLine Citation:
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PMID: 17706398 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We explored the effects of particulate matter <10 microm (PM(10)) exposure along with CYP1A1 polymorphisms of MspI (T6235C) and NcoI (Ile462Val) on reduced birth weight (BW). A prospective cohort study was done with women who delivered from 2001 to 2004 at Ewha Womans University Hospital, Seoul, Korea. We compared the estimated least squares means of BW in the generalized linear model, after adjusting for controlling factors. High PM(10) exposure at the 90th percentile level and above during the 1st trimester conferred a significant risk for reduced BW, compared with low PM(10) exposure below the 90th percentile level. The effect of high PM(10) exposure during the 1st trimester of pregnancy compared with low PM(10) exposure was greater for women with MspI TC/CC and NcoI IleVal/ValVal genotypes than for those with MspI TT and NcoI IleIle genotypes. In conclusion, high PM(10) exposure during the 1st trimester increased the risk for reduced BW in concert with MspI TC/CC and NcoI IleVal/ValVal genotypes in Korean women. |
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Authors:
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Young-Ju Suh; Byung-Mi Kim; Bo-Hyun Park; Hyesook Park; Young-Ju Kim; Ho Kim; Yun-Chul Hong; Eun-Hee Ha |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-07-07 |
Journal Detail:
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Title: Reproductive toxicology (Elmsford, N.Y.) Volume: 24 ISSN: 0890-6238 ISO Abbreviation: Reprod. Toxicol. Publication Date: 2007 Nov-Dec |
Date Detail:
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Created Date: 2007-11-06 Completed Date: 2008-01-08 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 8803591 Medline TA: Reprod Toxicol Country: United States |
Other Details:
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Languages: eng Pagination: 281-8 Citation Subset: IM |
Affiliation:
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Department of Preventive Medicine, College of Medicine, Ewha Medical Research Center, Ewha Womans University, Yangcheon-Ku, Seoul, Republic of Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Birth Weight / drug effects* Cohort Studies Cytochrome P-450 CYP1A1 / genetics*, metabolism DNA-Cytosine Methylases / genetics, metabolism Female Fetal Growth Retardation / epidemiology, etiology* Genetic Predisposition to Disease* / epidemiology Glycoproteins / genetics, metabolism Hospitals, University Humans Infant, Low Birth Weight / physiology* Infant, Newborn Korea / epidemiology Linkage (Genetics) Male Particle Size Particulate Matter / adverse effects* Polymorphism, Genetic* Pregnancy Prospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Glycoproteins; 0/Particulate Matter; 0/tissue-factor-pathway inhibitor 2; EC 1.14.14.1/Cytochrome P-450 CYP1A1; EC 2.1.1.-/DNA modification methylase NcoI; EC 2.1.1.-/DNA-Cytosine Methylases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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