Document Detail


Cytochrome P450 enzymes and the heart.
MedLine Citation:
PMID:  19787709     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The cytochrome P450 monooxygenase system (CYP) is a multigene superfamily of heme-thiolate enzymes, which are important in the metabolism of foreign and endogenous compounds. Genetic variations, drug interactions, or pathophysiological factors can lead to reduced, absent, or increased enzymatic activity. This altered CYP activity greatly influences an individual's response to therapeutic treatment. What is not known is the impact of these changes on the many functional roles of CYP in physiological and pathophysiological processes of the heart. Many extrahepatic tissues, like heart, contain active P450 enzymes but lack information regarding their role in cellular injury or homeostasis. Much of our current knowledge about cardiac CYP has been limited to studies investigating the role of fatty acid metabolites in heart. Traditional risk factors including diabetes, smoking, and hypertension have well established links to cardiovascular disease. And new evidence strongly suggests exposure to chemicals and other environmental agents has a profound impact on the cardiovascular system. These risk factors can independently affect the expression and activity of CYP enzymes. Therefore, altered CYP activity is important from a detoxification as well as a bioactivation perspective. Considering CYP, interactions are greatly dependent on inherited differences or acquired changes in enzyme activity further research into their potential impact on pathogenesis, risk assessment, and therapy of heart disease is warranted. This review explores the expression of CYP isoforms, their functional roles, and the effects of genetic variation in the heart.
Authors:
Ketul R Chaudhary; Sri Nagarjun Batchu; John M Seubert
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  IUBMB life     Volume:  61     ISSN:  1521-6551     ISO Abbreviation:  IUBMB Life     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-05     Completed Date:  2009-12-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888706     Medline TA:  IUBMB Life     Country:  England    
Other Details:
Languages:  eng     Pagination:  954-60     Citation Subset:  IM    
Affiliation:
Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, T6G 2N8, Canada.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cardiovascular System / metabolism
Cytochrome P-450 Enzyme System / metabolism*
Forecasting
Gene Expression Regulation, Enzymologic
Humans
Myocardium / metabolism*
Pharmacogenetics
Polymorphism, Genetic
Protein Isoforms / genetics,  metabolism
Substrate Specificity / genetics
Chemical
Reg. No./Substance:
0/Protein Isoforms; 9035-51-2/Cytochrome P-450 Enzyme System

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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