Document Detail

Cytochrome P450 II D6 gene polymorphisms and the neuroleptic-induced extrapyramidal symptoms in Japanese schizophrenic patients.
MedLine Citation:
PMID:  12960748     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of this study was to examine whether the neuroleptic-induced extrapyramidal symptoms are associated with the CYP2D6 activity. METHODS: The CYP2D6 gene polymorphisms (CYP2D6*2, CYP2D6*3, CYP2D6*4, CYP2D6*10, and CYP2D6*12) were genotyped in 196 normal controls and 320 schizophrenic patients receiving neuroleptics. The relationships with susceptibility to extrapyramidal symptoms (EPS) and tardive dyskinesia, and with steady-state serum haloperidol levels in maintenance therapy, were investigated. RESULTS: The allele frequency of CYP2D6*2 was significantly higher, while that of CYP2D6*10 tended to be higher in the schizophrenic patients susceptible to acute EPS. The steady-state serum haloperidol levels per daily dosage were observed to be significantly higher in schizophrenic patients with the mutant-type homozygote of CYP2D6*2, while this difference was trend level in those of CYP2D6*10. However, no significant difference was observed in the distribution of both CYP2D6*2 (C2938T) and CYP2D6*10 (C188T) polymorphisms between schizophrenic patients with or without tardive dyskinesia. CONCLUSION: The present results suggest that the homozygotes of CYP2D6*2 and CYP2D6*10 appear to be a susceptibility factor for developing acute EPS in schizophrenic patients and for impaired neuroleptic metabolism in Japanese schizophrenic patients.
Toshiya Inada; Hisashi Senoo; Yoshimi Iijima; Tadamitsu Yamauchi; Gohei Yagi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Psychiatric genetics     Volume:  13     ISSN:  0955-8829     ISO Abbreviation:  Psychiatr. Genet.     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-09-08     Completed Date:  2004-05-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9106748     Medline TA:  Psychiatr Genet     Country:  England    
Other Details:
Languages:  eng     Pagination:  163-8     Citation Subset:  IM    
National Institute of Mental Health, National Center of Neurology and Psychiatry, Chiba, Japan.
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MeSH Terms
Antipsychotic Agents / adverse effects*
Basal Ganglia Diseases / chemically induced,  genetics*
Cytochrome P-450 CYP2D6 / genetics*
Gene Frequency
Genetic Predisposition to Disease / genetics
Polymorphism, Genetic / genetics*
Reference Values
Schizophrenia / enzymology,  genetics*
Reg. No./Substance:
0/Antipsychotic Agents; EC P-450 CYP2D6

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