| Cytochrome P450 CYP2E1 knockout mice are protected against high fat diet induced obesity and insulin resistance. | |
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MedLine Citation:
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PMID: 22185839 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Conventional (whole body) CYP2E1 knockout mice displayed protection against high fat diet induced weight gain, obesity and hyperlipidemia with increased energy expenditure despite normal food intake and spontaneous locomotor activity. In addition, the CYP2E1 knockout mice displayed a marked improvement in glucose tolerance on both a normal chow and high fat diet. Euglycemic-hyperinsulinemic clamps demonstrated a marked protection against high fat diet induced insulin resistance in CYP2E1 knockout mice with enhanced adipose tissue glucose uptake and insulin suppression of hepatic glucose output. In parallel, adipose tissue was protected against high fat diet induced pro-inflammatory cytokine production. Taken together, these data demonstrate the CYP2E1 deletion protects mice against high fad diet induced insulin resistance with improved glucose homeostasis in vivo. |
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Authors:
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Haihong Zong; Michal Armoni; Chava Harel; Eddy Karnieli; Jeffrey E Pessin |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-20 |
Journal Detail:
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Title: American journal of physiology. Endocrinology and metabolism Volume: - ISSN: 1522-1555 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901226 Medline TA: Am J Physiol Endocrinol Metab Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1Albert Einstein College of Medicine. |
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