Document Detail


Cytochrome P-450-dependent O-dealkylase activity in mammalian skin.
MedLine Citation:
PMID:  6978749     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1 A modified technique for the measurement of O-dealkylase (ODA) activity in crude homogenates is reported, and its application to skin is described. 2 Large differences in ODA levels were found between different species, no activity being observed in the skin of primates. 3 Induction of cutaneous ODA in mice was achieved by the subcutaneous injection of phenobarbitone, hexachlorobenzene or 20-methylcholanthrene. 4 Attempts to induce ODA in vitro were unsuccessful.
Authors:
F J Damen; P D Mier
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  British journal of pharmacology     Volume:  75     ISSN:  0007-1188     ISO Abbreviation:  Br. J. Pharmacol.     Publication Date:  1982 Jan 
Date Detail:
Created Date:  1982-07-22     Completed Date:  1982-07-22     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7502536     Medline TA:  Br J Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  123-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
7-Alkoxycoumarin O-Dealkylase
Adolescent
Adult
Animals
Cattle
Cytochrome P-450 Enzyme System / metabolism*
Enzyme Induction / drug effects
Female
Hexachlorobenzene / pharmacology
Humans
Kinetics
Liver / enzymology
Macaca mulatta
Male
Methylcholanthrene / pharmacology
Mice
Mice, Hairless
Mice, Inbred A
Mice, Inbred BALB C
Oxygenases / analysis,  biosynthesis*
Phenobarbital / pharmacology
Rabbits
Rats
Skin / enzymology*
Species Specificity
Chemical
Reg. No./Substance:
118-74-1/Hexachlorobenzene; 50-06-6/Phenobarbital; 56-49-5/Methylcholanthrene; 9035-51-2/Cytochrome P-450 Enzyme System; EC 1.13.-/Oxygenases; EC 1.14.13.-/7-Alkoxycoumarin O-Dealkylase
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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