| Cytochrome P-450 2D6 and 2C19 polymorphisms and length of hospitalization in psychiatry. | |
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MedLine Citation:
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PMID: 16812949 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We evaluated whether cytochrome P450 (CYP) poor metabolizer polymorphisms of CYP2D6 and CYP2C19 are relevant for the outcome (measured by length of hospitalization) during treatment with psychotropic medications in patients with depression or schizophrenia. 229 patients were genotyped by real-time PCR hybridization probe melting curve technique for CYP2C19*2, CYP2D6*3, *4, and *6, respectively. The gene deletion CYP2D6*5 was analyzed by a long PCR method. Detailed clinical information was obtained from 53 subjects. Patients genotyped homozygous or heterozygous for those CYP2D6 and CYP2C19 poor metabolizer alleles were treated for a longer time in hospital (median 57.5 vs. 40.0 days). Psychiatric patients might benefit from CYP genotyping, the duration of stay as inpatient might be reduced by a priori selection of the appropriate drug for the individual patient. |
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Authors:
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Stefan Kropp; Ralf Lichtinghagen; Kathrin Winterstein; Jann Schlimme; Udo Schneider |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical laboratory Volume: 52 ISSN: 1433-6510 ISO Abbreviation: Clin. Lab. Publication Date: 2006 |
Date Detail:
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Created Date: 2006-07-03 Completed Date: 2006-07-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9705611 Medline TA: Clin Lab Country: Germany |
Other Details:
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Languages: eng Pagination: 237-40 Citation Subset: IM |
Affiliation:
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Department of Clinical Psychiatry and Psychotherapy, Hannover Medical School, Hannover, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aryl Hydrocarbon Hydroxylases
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genetics* Cytochrome P-450 CYP2D6 / genetics* Depression / drug therapy*, metabolism European Continental Ancestry Group Genotype Hospitals, Psychiatric Humans Length of Stay* Middle Aged Mixed Function Oxygenases / genetics* Pilot Projects Polymorphism, Genetic Psychotropic Drugs / metabolism, therapeutic use* Schizophrenia / drug therapy*, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Psychotropic Drugs; EC 1.-/Mixed Function Oxygenases; EC 1.14.14.1/Aryl Hydrocarbon Hydroxylases; EC 1.14.14.1/CYP2C19 protein, human; EC 1.14.14.1/Cytochrome P-450 CYP2D6 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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