Document Detail

Cytochemistry of sialoglycoconjugates, lysozyme, and β-defensin in eccrine glands of porcine snout skin as studied by electron microscopy.
MedLine Citation:
PMID:  23032992     Owner:  NLM     Status:  Publisher    
In most mammals except for humanoid primates, eccrine glands are confined to the skin of a series of specific body regions. Sialic acids and antimicrobial substances exhibit various functional properties and serve as a component of nonspecific defense against micro-organisms, respectively. In this study, the distribution of these moieties was studied by electron microscopic histochemical methods. The eccrine glandular acini consisted of two types of dark cells as well as clear cells. The secretory granules and Golgi apparatus of both types of dark cells contained sialic acid residues linked to α2-6Gal/GalNAc. On the other hand, sialoglycoconjugates with Siα2-3Galβ1-4GlcNAc sequence were confined to those of the Type II dark cells. In addition, lysozyme and β-defensin were mainly detected in the secretory granules of the Type II dark cells. These secretory products may create a defensive barrier against microbial invasion and play an essential role in preservation of the integrity of porcine snout skin as a sensory organ. Microsc. Res. Tech. 2012. © 2012 Wiley Periodicals, Inc.
Kousuke Fukui; Tadashi Yasui; Hiroshi Gomi; Hiroshi Sugiya; Osamu Fujimori; Wilfriend Meyer; Azuma Tsukise
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-3
Journal Detail:
Title:  Microscopy research and technique     Volume:  -     ISSN:  1097-0029     ISO Abbreviation:  Microsc. Res. Tech.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9203012     Medline TA:  Microsc Res Tech     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
Department of Veterinary Anatomy, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa 252-0880, Japan.
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