Document Detail

Cytochemical analysis of the chromatin of liver cell nuclei and nuclei of oval cells by means of the Feulgen hydrolysis curve in rats treated by thioacetamide.
MedLine Citation:
PMID:  6205835     Owner:  NLM     Status:  MEDLINE    
The present study is an analysis of the Feulgen hydrolysis characteristics in nuclei of liver cells and oval cells in rats treated by thioacetamide (TAA) and of liver cells in control rats. The curves show a double-peaked pattern. A slower hydrolysis is noted in the first peak after TAA treatment. This suggests an alteration of the acid-labile part of the chromatin. The curve obtained in the oval cells is different from the one in the liver cells. The implications of these differences are discussed with respect to development of cholangiocarcinomas.
M Praet; H Roels
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cytometry     Volume:  5     ISSN:  0196-4763     ISO Abbreviation:  Cytometry     Publication Date:  1984 Jul 
Date Detail:
Created Date:  1984-10-01     Completed Date:  1984-10-01     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  8102328     Medline TA:  Cytometry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  364-7     Citation Subset:  IM    
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MeSH Terms
Acetamides / pharmacology*
Cell Nucleus / drug effects*
Chromatin / drug effects*
Coloring Agents
Liver / cytology*,  drug effects
Rats, Inbred Lew
Rosaniline Dyes*
Staining and Labeling
Thioacetamide / pharmacology*
Reg. No./Substance:
0/Acetamides; 0/Chromatin; 0/Coloring Agents; 0/Feulgen stain; 0/Rosaniline Dyes; 62-55-5/Thioacetamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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