Document Detail


Cytoarchitecture and fiber pattern of the superior colliculus are disrupted in the Shaking Rat Kawasaki.
MedLine Citation:
PMID:  12644243     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Shaking Rat Kawasaki (SRK) is a Reelin-deficient rat, that shows significant cytoarchitectural abnormalities in the cerebral and cerebellar cortices in a similar manner to the reeler malformation. In the present study, we investigated the cytoarchitecture and myeloarchitecture of the superior colliculus (SC) of this mutant rat. The Nissl staining clearly showed that neuronal components in the superficial layers of the SC in SRK rat were intermingled with each other and that the boundaries between these superficial layers were blurred. The MBP immunohistochemistry showed an abnormal fiber pattern in the superficial layers of the SC of this mutant rat. In the normal rat, myelinated fibers passed rostrocaudally through the optic layer, and only a few myelinated fibers were recognized in the uppermost two layers, i.e., the zonal and superficial gray layers. By contrast, in SRK rat, the myelinated fibers were distributed throughout the entire thickness of the superficial layers of the SC. Anterograde labeling of retinotectal fibers with an injection of Cholera Toxin subunit B into the retina revealed that this abnormal fiber pattern was associated with the anomalous course of the retinotectal fibers. No distinct differences in the cytoarchitecture and fiber pattern in the deep layers of the SC were seen. In conclusion, the present study demonstrated that the cytoarchitecture and fiber patterning in the superficial layers of the SC were disrupted in SRK rat, suggesting that Reelin protein regulates the formation of the superficial layers of the SC.
Authors:
Shunsuke Sakakibara; Kazuyo Misaki; Toshio Terashima
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain research. Developmental brain research     Volume:  141     ISSN:  0165-3806     ISO Abbreviation:  Brain Res. Dev. Brain Res.     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-03-19     Completed Date:  2003-06-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8908639     Medline TA:  Brain Res Dev Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1-13     Citation Subset:  IM    
Copyright Information:
Copyright 2002 Elsevier Science B.V.
Affiliation:
Department of Anatomy and Developmental Neurobiology, Kobe University School of Medicine, 7-5-1, Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Patterning / genetics*
Cell Adhesion Molecules, Neuronal / deficiency*,  genetics
Cell Communication / genetics
Cell Differentiation / genetics
Cholera Toxin / metabolism
Extracellular Matrix Proteins / deficiency*,  genetics
Female
Fetus
Gene Deletion
Gene Expression Regulation, Developmental / genetics
Growth Cones / metabolism,  ultrastructure
Immunohistochemistry
Male
Nerve Fibers, Myelinated / metabolism*,  ultrastructure
Nerve Tissue Proteins
Neurons / cytology,  metabolism*
Pregnancy
Rats
Rats, Mutant Strains
Rats, Wistar
Retina / abnormalities*,  cytology,  metabolism
Serine Endopeptidases
Superior Colliculi / abnormalities*,  cytology,  metabolism
Visual Pathways / abnormalities*,  cytology,  metabolism
Chemical
Reg. No./Substance:
0/Cell Adhesion Molecules, Neuronal; 0/Extracellular Matrix Proteins; 0/Nerve Tissue Proteins; 9012-63-9/Cholera Toxin; EC 3.4.21.-/Serine Endopeptidases; EC 3.4.21.-/reelin protein

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