Document Detail

Cytoarchitectonic development of the prefrontal cortex in the rat.
MedLine Citation:
PMID:  2418068     Owner:  NLM     Status:  MEDLINE    
This paper gives an account of the cytoarchitectonic characteristics that make it possible to delineate, from as early as day 6, different subareas of the prefrontal cortex of the rat. Three phases can be distinguished during postnatal development. The first phase (from day 1 until day 18) is dominated by differentiation of the neurons within the cortical plate and by the formation of the cortical layers. At day 1, regional differences are observed in the cytoarchitecture of the cortical plate which correspond to the future subareas of the prefrontal cortex. The formation of layer IV occurs in the dorsolateral cortex around day 6, and from this age the agranular prefrontal cortex is well demarcated from the other parts of the frontal cortex. Between day 6 and day 10, the cortical plate has disappeared and all cortical layers can be recognized in the prefrontal cortex. Differentiation of the cells within the cortical layers changes the cytoarchitectonic character of the layers through day 18. During the second phase (from day 18 until day 30) little change occurs in the cytoarchitectonic characteristics of the prefrontal subareas. During the third phase (from day 30 until day 90) the delineation of the cortical layers becomes less clear in Nissl-stained sections, and the individual cytoarchitectonic variance increases. On the basis of cytoarchitectonic criteria it can be concluded that the orbital prefrontal cortex develops earlier than does the medial prefrontal cortex.
C G Van Eden; H B Uylings
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of comparative neurology     Volume:  241     ISSN:  0021-9967     ISO Abbreviation:  J. Comp. Neurol.     Publication Date:  1985 Nov 
Date Detail:
Created Date:  1986-03-12     Completed Date:  1986-03-12     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0406041     Medline TA:  J Comp Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  253-67     Citation Subset:  IM    
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MeSH Terms
Animals, Newborn / growth & development
Cell Differentiation
Frontal Lobe / anatomy & histology,  growth & development*
Gyrus Cinguli / anatomy & histology,  growth & development
Neurons / physiology
Rats, Inbred Strains / anatomy & histology*
Staining and Labeling
Thalamus / anatomy & histology,  growth & development

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