| Cyto-morphologic evaluation of bone marrow in infants with disseminated neuroblastoma. | |
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MedLine Citation:
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PMID: 22367387 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We studied the prevalence and degree of tumor cell infiltration (TCI) in bone marrow (BM) aspirates of 89 infants with stage 4/4 S neuroblastoma and correlated them with MYCN gene status and patient outcome. TCI was scored 0, +, ++, and +++, the last corresponding to an infiltration greater than 10%. TCI 0 was more frequent in stage 4 than in stage 4 S. TCI + and ++ were equally represented. TCI +++ was found only in 9 patients, all with typical stage 4 features (bone or lung involvement). Overall survival was not significantly influenced by the presence and degree of TCI. |
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Authors:
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Stefania Sorrentino; Cristina Rosanda; Stefano Parodi; Anna Rita Gigliotti; Mirella Pasino; Raffaella Defferrari; Gian Paolo Tonini; Bruno De Bernardi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of pediatric hematology/oncology Volume: 34 ISSN: 1536-3678 ISO Abbreviation: J. Pediatr. Hematol. Oncol. Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-02-27 Completed Date: 2012-04-09 Revised Date: 2012-04-16 |
Medline Journal Info:
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Nlm Unique ID: 9505928 Medline TA: J Pediatr Hematol Oncol Country: United States |
Other Details:
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Languages: eng Pagination: 154-8 Citation Subset: IM |
Affiliation:
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Department of Haematology-Oncology, Giannina Gaslini Children's Hospital, National Cancer Research Institute, Genova, Italy. sorryste@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Bone Marrow
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pathology* Bone Marrow Neoplasms / pathology Female Humans Infant Kaplan-Meier Estimate Male Neoplasm Staging Neuroblastoma / genetics, mortality, secondary* Nuclear Proteins / genetics Oncogene Proteins / genetics |
| Chemical | |
Reg. No./Substance:
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0/MYCN protein, human; 0/Nuclear Proteins; 0/Oncogene Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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