Document Detail

Cyto-morphologic evaluation of bone marrow in infants with disseminated neuroblastoma.
MedLine Citation:
PMID:  22367387     Owner:  NLM     Status:  MEDLINE    
We studied the prevalence and degree of tumor cell infiltration (TCI) in bone marrow (BM) aspirates of 89 infants with stage 4/4 S neuroblastoma and correlated them with MYCN gene status and patient outcome. TCI was scored 0, +, ++, and +++, the last corresponding to an infiltration greater than 10%. TCI 0 was more frequent in stage 4 than in stage 4 S. TCI + and ++ were equally represented. TCI +++ was found only in 9 patients, all with typical stage 4 features (bone or lung involvement). Overall survival was not significantly influenced by the presence and degree of TCI.
Stefania Sorrentino; Cristina Rosanda; Stefano Parodi; Anna Rita Gigliotti; Mirella Pasino; Raffaella Defferrari; Gian Paolo Tonini; Bruno De Bernardi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of pediatric hematology/oncology     Volume:  34     ISSN:  1536-3678     ISO Abbreviation:  J. Pediatr. Hematol. Oncol.     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-02-27     Completed Date:  2012-04-09     Revised Date:  2012-04-16    
Medline Journal Info:
Nlm Unique ID:  9505928     Medline TA:  J Pediatr Hematol Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  154-8     Citation Subset:  IM    
Department of Haematology-Oncology, Giannina Gaslini Children's Hospital, National Cancer Research Institute, Genova, Italy.
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MeSH Terms
Bone Marrow / pathology*
Bone Marrow Neoplasms / pathology
Kaplan-Meier Estimate
Neoplasm Staging
Neuroblastoma / genetics,  mortality,  secondary*
Nuclear Proteins / genetics
Oncogene Proteins / genetics
Reg. No./Substance:
0/MYCN protein, human; 0/Nuclear Proteins; 0/Oncogene Proteins

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