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Cyto-Morphologic Evaluation of Bone Marrow in Infants With Disseminated Neuroblastoma.
MedLine Citation:
PMID:  22082745     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
We studied the prevalence and degree of tumor cell infiltration (TCI) in bone marrow (BM) aspirates of 89 infants with stage 4/4 S neuroblastoma and correlated them with MYCN gene status and patient outcome. TCI was scored 0, +, ++, and +++, the last corresponding to an infiltration greater than 10%. TCI 0 was more frequent in stage 4 than in stage 4 S. TCI + and ++ were equally represented. TCI +++ was found only in 9 patients, all with typical stage 4 features (bone or lung involvement). Overall survival was not significantly influenced by the presence and degree of TCI.
Authors:
Stefania Sorrentino; Cristina Rosanda; Stefano Parodi; Anna Rita Gigliotti; Mirella Pasino; Raffaella Defferrari; Gian Paolo Tonini; Bruno De Bernardi
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-11
Journal Detail:
Title:  Journal of pediatric hematology/oncology     Volume:  -     ISSN:  1536-3678     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9505928     Medline TA:  J Pediatr Hematol Oncol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
*Department of Haematology-Oncology, Giannina Gaslini Children's Hospital †Clinical Epidemiology Unit, Department of Epidemiology and Prevention ‡Translational Oncopathology and Laboratory of the Italian Neuroblastoma Foundation, National Cancer Research Institute, Genova, Italy.
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