| Cyto-Morphologic Evaluation of Bone Marrow in Infants With Disseminated Neuroblastoma. | |
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MedLine Citation:
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PMID: 22082745 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We studied the prevalence and degree of tumor cell infiltration (TCI) in bone marrow (BM) aspirates of 89 infants with stage 4/4 S neuroblastoma and correlated them with MYCN gene status and patient outcome. TCI was scored 0, +, ++, and +++, the last corresponding to an infiltration greater than 10%. TCI 0 was more frequent in stage 4 than in stage 4 S. TCI + and ++ were equally represented. TCI +++ was found only in 9 patients, all with typical stage 4 features (bone or lung involvement). Overall survival was not significantly influenced by the presence and degree of TCI. |
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Authors:
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Stefania Sorrentino; Cristina Rosanda; Stefano Parodi; Anna Rita Gigliotti; Mirella Pasino; Raffaella Defferrari; Gian Paolo Tonini; Bruno De Bernardi |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-11 |
Journal Detail:
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Title: Journal of pediatric hematology/oncology Volume: - ISSN: 1536-3678 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9505928 Medline TA: J Pediatr Hematol Oncol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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*Department of Haematology-Oncology, Giannina Gaslini Children's Hospital †Clinical Epidemiology Unit, Department of Epidemiology and Prevention ‡Translational Oncopathology and Laboratory of the Italian Neuroblastoma Foundation, National Cancer Research Institute, Genova, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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