Document Detail


Cytarabine and highly active antiretroviral therapy in HIV-related progressive multifocal leukoencephalopathy.
MedLine Citation:
PMID:  10751117     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We assessed survival in AIDS-related progressive multifocal leukoencephalopathy (PML) and the effect of cytarabine and antiretroviral therapy in a retrospective analysis of a series of consecutive 35 patients with AIDS-related PML in an academic AIDS referral center over 15 years. Treatment regimens consisted of highly active antiretroviral treatment (HAART), intravenous cytarabine, or both. Median survival after diagnosis in the overall series was 88 days. Patients with low CD4 cell count tended to have shorter survival. Seven patients (20%) had prolonged survival (> 1 year). Cytarabine did not affect survival. Seven patients were treated with HAART, which did not significantly improve survival. We conclude that the prognosis of AIDS-related PML is still poor, with a median survival of 3 months.
Authors:
R H Enting; P Portegies
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neurology     Volume:  247     ISSN:  0340-5354     ISO Abbreviation:  J. Neurol.     Publication Date:  2000 Feb 
Date Detail:
Created Date:  2000-05-19     Completed Date:  2000-05-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0423161     Medline TA:  J Neurol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  134-8     Citation Subset:  IM; X    
Affiliation:
Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Cytarabine / therapeutic use*
Female
HIV Infections / complications*,  drug therapy*
Humans
Leukoencephalopathy, Progressive Multifocal / complications*,  drug therapy*
Male
Middle Aged
Chemical
Reg. No./Substance:
147-94-4/Cytarabine

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