Document Detail

Cystinuria: the South Indian experience.
MedLine Citation:
PMID:  19779707     Owner:  NLM     Status:  MEDLINE    
Cystinuria is reportedly a rare condition affecting the stone patients in India. This paper presents the occurrence of cystine-related abnormality in the population of stone patients reporting to the hospitals in South India. Two thousand and eight hundred urine samples from 1,300 patients attending the urinary stone clinic during the period 2004-2008 were assessed for cystinuria by performing the nitroprusside test on the early morning urine and random samples on the day of attendance. Urinary deposits were also studied in all the patients. Stones retrieved from 800 stone patients were analysed qualitatively and by Fourier Transform infra red (FTIR) spectroscopy. Cystinuria was identified in only three patients. None of these patients showed cystine crystals. Three other patients out of the 1,300 showed presence of cystine crystals in the urine deposit. FTIR spectroscopy of the stones retrieved from the patients showed presence of cystine in 19 out of the 800 stones analysed (2.375%). None of the patients with cystine in the stones had either cystine crystals in the urine or positive nitroprusside test for cystine. All the patients who had positive cystine, cystine crystals or cystine in stone analysis had other biochemical abnormalities. They were medically managed with appropriate biochemical corrective chemotherapy and had control of stone disease process. All the patients were advised purine restriction in the diet. It is concluded from the study that cystinuria is a rare entity in South India. It, however, exists in a small percentage of stone patients. Specific treatment with D-penicillamine was not administered to the patients in view of the high cost, nonavailability and possible toxicity. The patients considered above did not have intractable stone disease which was not amenable to usual modalities of directed medical therapy.
Y M Fazil Marickar
Related Documents :
21042037 - Update of the atlanta classification of severity of acute pancreatitis: should a modera...
23544447 - Germinal-center type b-cell classification and clinical characteristics of chinese pedi...
24558527 - Osteonecrosis of the jaws in patients treated with bisphosphonates.
24989987 - Azacitidine for myelodysplastic patients aged > 65 years: a review of clinical efficacy.
25440397 - Management of peri-operative anti-thrombotic therapy.
21629067 - Evaluation of prophylactic anticoagulation, deep venous thrombosis, and heparin-induced...
Publication Detail:
Type:  Journal Article     Date:  2009-09-25
Journal Detail:
Title:  Urological research     Volume:  37     ISSN:  1434-0879     ISO Abbreviation:  Urol. Res.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2010-01-29     Completed Date:  2010-05-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0364311     Medline TA:  Urol Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  341-3     Citation Subset:  IM    
Department of Surgery, Zensa Hospital, Trivandrum, 695009, India.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cysteine / metabolism
Cystinuria / epidemiology*,  ethnology,  metabolism
India / epidemiology
Retrospective Studies
Spectroscopy, Fourier Transform Infrared
Urinary Calculi / epidemiology*,  ethnology,  metabolism
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Calcium oxalate stone and gout.
Next Document:  Female stone disease: the changing trend.