| Cystine: helical computerized tomography characterization of rough and smooth calculi in vitro. | |
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MedLine Citation:
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PMID: 16145473 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: The classification of cystine stones into rough and smooth varieties has been suggested as an aid to choosing treatment for these difficult stones. Since the surface of stones is difficult to visualize preoperatively, we tested the hypothesis that the surface morphology of cystine stones correlates with their internal structure, as viewed by helical computerized tomography (CT). MATERIALS AND METHODS: Cystine stones were examined visually and categorized into rough (15 stones) and smooth (16 stones) subpopulations of similar size. Each stone was scanned in a helical CT scanner (GE Quad Scanner) to assess radiological characteristics and to measure attenuation values. Scans were also performed using a microCT 20 high resolution laboratory scanner (Scanco Medical AG, Bassersdorf, Switzerland) at 34 microm voxel size and the percent of internal voids was determined. RESULTS: Mean helical CT attenuation values +/- SD for rough stones were lower than for smooth stones (702 +/- 206 vs 921 +/- 51 HU, p <0.002) and the radiological appearance of rough stones suggested radiolucent voids. Internal voids in rough stones were confirmed using micro CT. Rough cystine stones contained a higher percent of internal voids (0.30% vs 0.06%, p <0.0001). CONCLUSIONS: Rough cystine stones can be distinguished from smooth stones using helical CT in vitro, suggesting that it may be possible to distinguish these stones preoperatively. Since rough cystine stones have been reported to be susceptible to shock wave lithotripsy, the identification of this morphology of cystine stones in the patient using attenuation values and appearance on helical CT could be valuable for planning treatment. |
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Authors:
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Samuel C Kim; Erin K Hatt; James E Lingeman; Robert B Nadler; James A McAteer; James C Williams |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of urology Volume: 174 ISSN: 0022-5347 ISO Abbreviation: J. Urol. Publication Date: 2005 Oct |
Date Detail:
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Created Date: 2005-09-07 Completed Date: 2005-10-19 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0376374 Medline TA: J Urol Country: United States |
Other Details:
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Languages: eng Pagination: 1468-70; discussion 1470-1 Citation Subset: AIM; IM |
Affiliation:
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Methodist Hospital Institute for Kidney Stone Disease, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cysteine
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analysis Humans Kidney Calculi / chemistry*, classification, radiography, therapy* Lithotripsy Tomography, Spiral Computed Urinary Calculi / chemistry*, classification, radiography*, therapy |
| Grant Support | |
ID/Acronym/Agency:
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P01DK43881/DK/NIDDK NIH HHS; R01DK55674/DK/NIDDK NIH HHS; R01DK59933/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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52-90-4/Cysteine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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