| Cystine and theanine supplementation restores high-intensity resistance exercise-induced attenuation of natural killer cell activity in well-trained men. | |
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MedLine Citation:
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PMID: 20145562 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated the effects of supplementation with cystine, a dipeptide of cysteine, and theanine (CT), a precursor of glutamate, on immune variables during high-intensity resistance exercise. Cysteine and glutamate are involved in the formation of glutathione, which modulates the activity of natural killer (NK) cells. In this double-blinded clinical trial, 15 well-trained men (aged 22.8 +/- 4.0 years) were divided into 2 groups: placebo (n = 7) and CT (n = 8). The placebo group was administered a powder containing cellulose (950 mg) and glutamate (30 mg), whereas the CT group was administered a powder containing cystine (700 mg) and theanine (280 mg), once daily for 2 weeks. The subjects trained according to their normal schedule (3 times per week) in the first week and trained at double the frequency (6 times per week) in the second week. Concentrations of immunoglobulin (Ig)M, interleukin (IL)-6, IL-8, and salivary IgA and the leukocyte count did not change significantly in either group. There was a significant decrease (p < or = 0.05) in the NK cell activity (NKCA) in the placebo group after the second week compared with that in the CT group (placebo: 69.2 +/- 16.1% vs. CT: 101.7 +/- 38.7%). Phytohemagglutinin-induced lymphocyte blastoid transformation did not change significantly in either group. These results suggest that NKCA is not affected in a normal training schedule with or without CT supplementation. However, high-intensity and high-frequency resistance exercises cause attenuation of NKCA, which CT supplementation appears to restore. Therefore, in practical application, CT supplementation would be useful for athletes to restore the attenuation of NKCA during high-intensity and high-frequency training. |
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Authors:
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Shigeo Kawada; Kando Kobayashi; Masaru Ohtani; Chiho Fukusaki |
Publication Detail:
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Type: Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of strength and conditioning research / National Strength & Conditioning Association Volume: 24 ISSN: 1533-4287 ISO Abbreviation: J Strength Cond Res Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-02 Completed Date: 2010-05-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9415084 Medline TA: J Strength Cond Res Country: United States |
Other Details:
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Languages: eng Pagination: 846-51 Citation Subset: IM |
Affiliation:
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Laboratory of Tissue Plasticity Science, Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan. kawada@idaten.c.u-tokyo.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cystine
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pharmacology* Dietary Supplements Double-Blind Method Glutamates / pharmacology* Humans Immunoglobulin A / analysis Immunoglobulin M / blood Interleukin-6 / blood Interleukin-8 / blood Killer Cells, Natural / drug effects*, physiology Leukocyte Count Male Resistance Training* / adverse effects Saliva / chemistry Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Glutamates; 0/Immunoglobulin A; 0/Immunoglobulin M; 0/Interleukin-6; 0/Interleukin-8; 3081-61-6/theanine; 56-89-3/Cystine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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