Document Detail

Cystic sebaceous neoplasms in Muir-Torre syndrome.
MedLine Citation:
PMID:  12708909     Owner:  NLM     Status:  MEDLINE    
Cystic sebaceous neoplasms have been seen only in patients with Muir-Torre syndrome (MTS) and have recently been characterized as marker lesions of MTS. Histologically, these lesions form a spectrum of tumors ranging from benign cystic adenomas to proliferative cystic sebaceous tumors. We describe 2 proliferative cystic sebaceous tumors in a 53-year-old man whose workup revealed colonic adenocarcinoma and other sebaceous tumors consistent with MTS. Both the chest wall and the left thigh masses were grossly cystic, measuring 1.0 and 1.5 cm, respectively. Histologic sections demonstrated well-circumscribed cystic neoplasms located in the deep dermis and subcutaneous tissue. Each had a focally infolded cyst wall composed of immature basaloid cells with prominent nucleoli and mitoses, consistent with a proliferative cystic sebaceous tumor. Recognition of cystic sebaceous neoplasm by pathologists and communication to clinicians of its strong association with MTS is of diagnostic importance.
Jared J Abbott; Pablo Hernandez-Rios; Robin H Amirkhan; Mai P Hoang
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Archives of pathology & laboratory medicine     Volume:  127     ISSN:  1543-2165     ISO Abbreviation:  Arch. Pathol. Lab. Med.     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-04-23     Completed Date:  2003-05-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7607091     Medline TA:  Arch Pathol Lab Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  614-7     Citation Subset:  AIM; IM    
Medical Scientist Training Program, the University of Texas Southwestern Medical Center, Dallas 75390-9073, USA.
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MeSH Terms
Adenocarcinoma / diagnosis*
Adenoma / diagnosis*
Carcinoma / diagnosis*
Cecal Neoplasms / diagnosis*
Colonic Neoplasms / diagnosis*
Middle Aged
Neoplasms, Cystic, Mucinous, and Serous / diagnosis*
Sebaceous Gland Neoplasms / diagnosis*
Skin Neoplasms / diagnosis
Subcutaneous Tissue / pathology
Thigh / pathology
Thoracic Wall / pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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