Document Detail

Cystic hydatic disease in sheep: treatment with percutaneous aspiration and injection with dipeptide methyl ester.
MedLine Citation:
PMID:  16502106     Owner:  NLM     Status:  MEDLINE    
An in vitro and in vivo study was conducted to show the effect of dipeptide methyl ester on the protoscolices of Echinococcus granulosus and in naturally infected sheep. Easily punctured cysts were located by ultrasonography. A PAIR and PAI method were performed by the injection of dipeptide methyl ester into these cysts at a final concentration of 110 mmol/L. Follow-up was conducted monthly by ultrasonography. After injection of the compound, the sheep were sacrificed at different times from 6 to 17 weeks. The size and the morphological aspect of treated cysts were noted. Samples were collected for histology and electron microscopy. In conclusion, these studies revealed significant and rapid detachment of the membrane of the treated cyst and alteration of the inner membrane in less than 5 min after injection of the drug, confirming the effect of the compound on the laminated layer of the parasite.
S Lahmar; M E Sarciron; F Ben Chehida; A Hammou; H A Gharbi; A Gherardi; J Lahmar; A Ghannay; A F Pétavy
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Veterinary research communications     Volume:  30     ISSN:  0165-7380     ISO Abbreviation:  Vet. Res. Commun.     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-02-27     Completed Date:  2007-03-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8100520     Medline TA:  Vet Res Commun     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  379-91     Citation Subset:  IM    
Parasitology Laboratory, National Veterinary School, Sidi Thabet, Tunisia.
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MeSH Terms
Anthelmintics / administration & dosage*,  therapeutic use*
Cysts / ultrastructure
Dipeptides / administration & dosage*,  therapeutic use*
Dose-Response Relationship, Drug
Echinococcosis, Hepatic / drug therapy,  pathology,  therapy,  veterinary*
Echinococcus granulosus / drug effects
Injections, Intralesional / methods,  veterinary
Sheep Diseases / drug therapy,  therapy*
Reg. No./Substance:
0/Anthelmintics; 0/Dipeptides; 13082-29-6/phenylalanylphenylalanine methyl ester

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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