Document Detail


Cystic gastrointestinal stromal tumors of the pancreas simulating cystoadenocarcinoma. Report of three cases and short review of the literature.
MedLine Citation:
PMID:  24918465     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Gastrointestinal stromal tumors represent a distinct subset of mesenchymal tumours of the gastrointestinal tract. They are more common in the stomach and small intestine, and are characterized by the proliferation of spindle or epithelioid cells and by the expression of CD117. Extra-gastrointestinal stromal tumors are rare and only 13 cases of pancreatic GISTs have been reported in the literature, only 1 of which presented as a cystic lesion. Mutational analysis of KIT and Platelet derived growth factor receptor-α genes was performed only in two out of the 13 cases. We report 3 cases of cystic GISTs of the pancreas, radiologically mimicking a cystoadenocarcinoma. Routine histopathology and molecular characterization of the tumours have been performed. In two of them, molecular characterization showed unusual genetic alterations (the internal repeat of codon 502 and 503 in exon 9 of the KIT gene and the KIT exon 9 single nucleotide substitution c.1427G⟩T). Pancreatic GIST should be included in the differential diagnosis of both cystic and solid masses of the pancreas. The diagnosis should be accomplished by a combination of radiology, histology, immunohistochemistry and molecular biology. The evaluation of CD117 expression and the sequence analysis of KIT and Platelet derived growth factor receptor-α gene is mandatory for therapy.
Authors:
M R Ambrosio; B J Rocca; M G Mastrogiulio; A Pesci; A De Martino; M A Mazzei; L Volterrani; F Arcuri; M Cintorino; S A Tripodi
Related Documents :
11906655 - Spongiotic vesicular dermatitis as a cutaneous reaction pattern in seven horses.
16031555 - Scrapie in goats in cyprus.
8831395 - Evidence for rapid accumulation and persistently disordered architecture of fibrillar c...
24918465 - Cystic gastrointestinal stromal tumors of the pancreas simulating cystoadenocarcinoma. ...
24570475 - Epley and beyond: an update on treating positional vertigo.
6594275 - Classification and diagnosis of pulpal pathoses.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-6-11
Journal Detail:
Title:  Histology and histopathology     Volume:  -     ISSN:  1699-5848     ISO Abbreviation:  Histol. Histopathol.     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-6-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8609357     Medline TA:  Histol Histopathol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Seven-Tesla Magnetic Resonance Imaging of Atherosclerotic Plaque in the Significantly Stenosed Carot...
Next Document:  Preparation and in vitro/in vivo evaluation of resveratrol-loaded carboxymethyl chitosan nanoparticl...