| Cystic fibrosis-related diabetes in children--gaps in the evidence? | |
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MedLine Citation:
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PMID: 20498678 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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As the life span of patients with cystic fibrosis has increased, so has the prevalence of cystic fibrosis-related diabetes mellitus. However, screening practices for cystic fibrosis-related diabetes mellitus vary widely, which affects accurate estimates of the health burden of this comorbidity. The management of prediabetes and hyperglycemia is an increasingly important aspect of care in patients with cystic fibrosis, but few studies have specifically addressed the management of cystic fibrosis-related diabetes mellitus. Previous studies support the use of insulin for the treatment of patients with this disorder, but the evidence for its use in patients with cystic fibrosis and impaired glucose tolerance is poor. Nutritional management is currently guided by dietary recommendations for individuals with cystic fibrosis, with little evidence specific to the dietary management of patients with cystic fibrosis-related diabetes mellitus. Additionally, microvascular complications have become more frequent as a result of the rise in life expectancy of these patients, yet to date no intervention studies have addressed prevention or management of diabetic complications in patients with cystic fibrosis. A strong evidence base is needed to guide the management of patients with cystic fibrosis-related diabetes mellitus and its complications. |
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Authors:
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Malay Rana; Craig F Munns; Hiran Selvadurai; Kim C Donaghue; Maria E Craig |
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Publication Detail:
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Type: Journal Article; Review Date: 2010-05-25 |
Journal Detail:
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Title: Nature reviews. Endocrinology Volume: 6 ISSN: 1759-5037 ISO Abbreviation: Nat Rev Endocrinol Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-23 Completed Date: 2010-09-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101500078 Medline TA: Nat Rev Endocrinol Country: England |
Other Details:
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Languages: eng Pagination: 371-8 Citation Subset: IM |
Affiliation:
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Department of Endocrinology and Diabetes, The Children's Hospital at Westmead, Locked Bag 4001, Westmead, 2145 NSW, Australia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Child Cystic Fibrosis / complications*, epidemiology*, metabolism, physiopathology Diabetes Mellitus / epidemiology*, etiology*, metabolism, physiopathology Humans |
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