| Cystic fibrosis in adolescents and adults: fatty replacement of the pancreas--CT evaluation and functional correlation. | |
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MedLine Citation:
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PMID: 10207457 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To compare the computed tomographic (CT) features of pancreatic fatty replacement in adolescents and adults with cystic fibrosis (CF) with those in control subjects and to correlate the degree of fatty replacement with the functional status of the pancreas. MATERIALS AND METHODS: CT scans in 15 patients with CF (group 1) and in 15 control subjects without CF (group 2) were evaluated for thickness and degree of pancreatic fatty replacement. Thickness was measured at four anatomic levels. The pattern of pancreatic fatty replacement was visually evaluated in four pancreatic regions. Images were semiquantitatively analyzed by two readers. The degree of fatty replacement was correlated with the functional status of the pancreas. RESULTS: In group 1, pancreatic glandular tissue was significantly thinner (P < .001) and the degree of fatty replacement was significantly greater in the four regions (P < .001) than those in group 2. In Group 1, no relationship was found between the degree of pancreatic fatty replacement and that of pancreatic endocrine dysfunction. A significant relationship was found between the degree of fatty replacement and that of pancreatic exocrine dysfunction (P < .001). CONCLUSION: In patients with CF, pancreatic glandular tissue is significantly reduced in size. Pancreatic fatty replacement is the most frequent pattern in older patients with CF and correlates with pancreatic exocrine dysfunction. |
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Authors:
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P Soyer; L Spelle; J P Pelage; A C Dufresne; Y Rondeau; M Gouhiri; A Scherrer; R Rymer |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Radiology Volume: 210 ISSN: 0033-8419 ISO Abbreviation: Radiology Publication Date: 1999 Mar |
Date Detail:
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Created Date: 1999-05-06 Completed Date: 1999-05-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0401260 Medline TA: Radiology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 611-5 Citation Subset: AIM; IM |
Affiliation:
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Department of Body and Vascular Imaging, Hôpital Lariboisière-AP-HP, Paris, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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physiopathology,
radiography* Adolescent Adult Case-Control Studies Contrast Media Cystic Fibrosis / physiopathology, radiography* Female Humans Islets of Langerhans / physiopathology Male Pancreas / physiopathology, radiography* Prospective Studies Radiographic Image Enhancement Single-Blind Method Tomography, X-Ray Computed* |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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