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Cystic "feminine" pancreatic neoplasms in men. Do any clinical alterations correlate with these uncommon entities?
MedLine Citation:
PMID:  23274554     Owner:  NLM     Status:  Publisher    
INTRODUCTION: Mucinous cystic neoplasm (MCN) and solid pseudopapillary neoplasm (SPN) of the pancreas are uncommon hormone-related pancreatic tumours (HRPTs) with a clear predominance in young women. This trial aims to investigate the possible association between HRPTs development in males and phenotypic and sex hormone alterations. METHODS: We performed a retrospective analysis of our database between February 1990 and February 2012. Risk factors for sexual dysfunction were considered exclusion criteria. We investigated secondary sexual characteristics development, sex hormone level and overall sexual dysfunction degree according with the International Index of Erectile Function Questionnaire (IIEF). RESULTS: We initially identified 25 patients [(MCN: n=16 (64%); SPN: n=9 (36%)]. At follow-up, 5 patients were lost, 8 resulted dead and 3 were excluded according with exclusion criteria. We finally enrolled 9 patients (MCN: n=5; SPN: n=4). Puberty occurred within physiological age for 7 patients, whereas it was delayed in 2 cases. Three patients revealed mild sexual dysfunction, along with low testosterone level in two cases. DISCUSSION: In this study, the first in literature with similar aim, hormonal and/or sexual dysfunction was present in 3 out 9 patients affected by HRPT. The rarity of these lesions makes further trials to be needed for reliable conclusions.
P Regi; R Salvia; C Cena; G Girelli; I Frigerio; C Bassi
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-27
Journal Detail:
Title:  International journal of surgery (London, England)     Volume:  -     ISSN:  1743-9159     ISO Abbreviation:  Int J Surg     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101228232     Medline TA:  Int J Surg     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Ltd.
Department of Surgery, HPB Unit, Casa di Cura Dott. Pederzoli, Peschiera Del Garda (Verona), Italy. Electronic address:
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