| Cysteinyl leukotriene blockade does not prevent acute mountain sickness. | |
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MedLine Citation:
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PMID: 15152893 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Acute Mountain Sickness (AMS) is a multi-system disorder that is characterized by headache, anorexia, nausea, vomiting, insomnia, lassitude, and malaise. The syndrome is common in unacclimatized low altitude residents who rapidly ascend to terrestrial elevations exceeding 2,500 m. AMS may be a manifestation of hypoxia-induced cerebral edema resulting, in part, from increased capillary permeability. HYPOTHESIS: We hypothesized that cysteinyl leukotrienes (CysLTs) may be involved in the pathogenesis of AMS, as these compounds are known to increase endothelial permeability. METHODS: To test this hypothesis, we orally administered a CysLTs type-1 receptor antagonist (montelukast) to 11 subjects prior to and during exposure to high altitude (4,300 m) in a hypobaric chamber in a randomized, placebo-controlled, crossover design. We measured the resulting prevalence and/or severity of AMS, plasma CysLTs levels and urinary CysLTE4, and associated physiological responses. RESULTS: At 12 h exposure, AMS prevalence and symptom severity was lower (p = 0.002) during montelukast administration compared with placebo, but not different at 22 h exposure. Plasma CysLTs and urinary LTE4 levels were not significantly elevated at 22 h exposure, nor did these CysLTs levels correlate with AMS severity. Compared with placebo, montelukast administration was not associated with any significant differences in physiologic measures at sea level or high altitude. CONCLUSIONS: These results do not support a role for the CysLTs mediating the early development of AMS through the CysLT-1 receptor. |
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Authors:
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Stephen R Muza; David Kaminsky; Charles S Fulco; Louis E Banderet; Allen Cymerman |
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8001533 - Physiological changes induced by pre-adaptation to high altitude. 18196263 - Extracellular ph defense against lactic acid in untrained and trained altitude residents. 779523 - The sensitivity of the respiratory center and some circulatory and subjective responses... |
Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Aviation, space, and environmental medicine Volume: 75 ISSN: 0095-6562 ISO Abbreviation: Aviat Space Environ Med Publication Date: 2004 May |
Date Detail:
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Created Date: 2004-05-21 Completed Date: 2004-09-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7501714 Medline TA: Aviat Space Environ Med Country: United States |
Other Details:
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Languages: eng Pagination: 413-9 Citation Subset: IM; S |
Affiliation:
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Thermal and Mountain Medicine Division, U.S. Army Research Institute of Environmental Medicine, Natick, MA 01760-5007, USA. Stephen.muza@us.army.mil |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetates
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administration & dosage,
pharmacology* Administration, Oral Adult Altitude Sickness / metabolism*, physiopathology, prevention & control* Analysis of Variance Chromatography, High Pressure Liquid Cross-Over Studies Cysteine / metabolism* Double-Blind Method Enzyme-Linked Immunosorbent Assay Female Humans Leukotriene Antagonists / administration & dosage, pharmacology* Leukotrienes / metabolism* Male Prevalence Quinolines / administration & dosage, pharmacology* Severity of Illness Index Statistics, Nonparametric Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Acetates; 0/Leukotriene Antagonists; 0/Leukotrienes; 0/Quinolines; 0/cysteinyl-leukotriene; 158966-92-8/montelukast; 52-90-4/Cysteine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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