Document Detail


Cysteinyl leukotriene blockade does not prevent acute mountain sickness.
MedLine Citation:
PMID:  15152893     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Acute Mountain Sickness (AMS) is a multi-system disorder that is characterized by headache, anorexia, nausea, vomiting, insomnia, lassitude, and malaise. The syndrome is common in unacclimatized low altitude residents who rapidly ascend to terrestrial elevations exceeding 2,500 m. AMS may be a manifestation of hypoxia-induced cerebral edema resulting, in part, from increased capillary permeability. HYPOTHESIS: We hypothesized that cysteinyl leukotrienes (CysLTs) may be involved in the pathogenesis of AMS, as these compounds are known to increase endothelial permeability. METHODS: To test this hypothesis, we orally administered a CysLTs type-1 receptor antagonist (montelukast) to 11 subjects prior to and during exposure to high altitude (4,300 m) in a hypobaric chamber in a randomized, placebo-controlled, crossover design. We measured the resulting prevalence and/or severity of AMS, plasma CysLTs levels and urinary CysLTE4, and associated physiological responses. RESULTS: At 12 h exposure, AMS prevalence and symptom severity was lower (p = 0.002) during montelukast administration compared with placebo, but not different at 22 h exposure. Plasma CysLTs and urinary LTE4 levels were not significantly elevated at 22 h exposure, nor did these CysLTs levels correlate with AMS severity. Compared with placebo, montelukast administration was not associated with any significant differences in physiologic measures at sea level or high altitude. CONCLUSIONS: These results do not support a role for the CysLTs mediating the early development of AMS through the CysLT-1 receptor.
Authors:
Stephen R Muza; David Kaminsky; Charles S Fulco; Louis E Banderet; Allen Cymerman
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Aviation, space, and environmental medicine     Volume:  75     ISSN:  0095-6562     ISO Abbreviation:  Aviat Space Environ Med     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-05-21     Completed Date:  2004-09-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7501714     Medline TA:  Aviat Space Environ Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  413-9     Citation Subset:  IM; S    
Affiliation:
Thermal and Mountain Medicine Division, U.S. Army Research Institute of Environmental Medicine, Natick, MA 01760-5007, USA. Stephen.muza@us.army.mil
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MeSH Terms
Descriptor/Qualifier:
Acetates / administration & dosage,  pharmacology*
Administration, Oral
Adult
Altitude Sickness / metabolism*,  physiopathology,  prevention & control*
Analysis of Variance
Chromatography, High Pressure Liquid
Cross-Over Studies
Cysteine / metabolism*
Double-Blind Method
Enzyme-Linked Immunosorbent Assay
Female
Humans
Leukotriene Antagonists / administration & dosage,  pharmacology*
Leukotrienes / metabolism*
Male
Prevalence
Quinolines / administration & dosage,  pharmacology*
Severity of Illness Index
Statistics, Nonparametric
Treatment Outcome
Chemical
Reg. No./Substance:
0/Acetates; 0/Leukotriene Antagonists; 0/Leukotrienes; 0/Quinolines; 0/cysteinyl-leukotriene; 158966-92-8/montelukast; 52-90-4/Cysteine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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