Document Detail

Cysteine and obesity: consistency of the evidence across epidemiologic, animal and cellular studies.
MedLine Citation:
PMID:  22108094     Owner:  NLM     Status:  Publisher    
PURPOSE OF REVIEW: The concentrations of several plasma amino acids increase in obesity. Notably, plasma total concentrations of the sulphur amino acid cysteine (tCys) are linearly associated with fat mass in large population studies. Animal and cellular experiments support the concept that cysteine may be obesogenic. Here we review experimental and epidemiologic findings linking cysteine and related compounds with fat regulation and obesity. RECENT FINDINGS: tCys, and to a lesser extent cystathionine, are the only plasma sulphur amino acids consistently associated with human obesity, whereas glutathione is inversely associated with BMI. Supplementing cyste(i)ne in rodents decreases energy expenditure and promotes adiposity, whereas defects of cysteine-synthesizing enzymes decrease body weight. In adipocytes, cysteine inhibits lipolysis and promotes lipogenesis via H2O2 production. Unlike most plasma amino acids, tCys levels do not decrease with gastric bypass-induced weight loss, further supporting the concept that elevated cysteine may be a cause, not a consequence of obesity. Although cysteine products (glutathione, taurine and H2S) are altered in obesity, they do not appear to explain cysteine's effects on body weight. SUMMARY: Cellular, animal and epidemiologic data are consistent with the view that cysteine is obesogenic. Targeted research linking in-vitro and in-vivo findings is needed to elucidate mechanisms involved.
Amany K Elshorbagy; Viktor Kozich; A David Smith; Helga Refsum
Related Documents :
1907814 - Bioassay for siderophore utilization by candida albicans.
15837384 - Purification and characterization of mycoferritin from aspergillus parasiticus (255).
18960204 - Titrimetric, coulometric and spectrophotometric determination of manganese following pe...
6418154 - Lipoxygenase from rabbit reticulocytes: iron content, amino acid composition and c-term...
17902054 - Chondroitin c lyase [4.2.2.] is unable to cleave fructosylated sequences inside the par...
19180454 - Aib and iva in the biosphere: neither rare nor necessarily extraterrestrial.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-19
Journal Detail:
Title:  Current opinion in clinical nutrition and metabolic care     Volume:  -     ISSN:  1535-3885     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9804399     Medline TA:  Curr Opin Clin Nutr Metab Care     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
aDepartment of Pharmacology, University of Oxford, Oxford, UK bDepartment of Physiology, Faculty of Medicine, University of Alexandria, Alexandria, Egypt cInstitute of Inherited Metabolic Disorders, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic dDepartment of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Polypharmacy and nutritional status in elderly people.
Next Document:  Phytochemicals suppress nuclear factor-?B signaling: impact on health span and the aging process.