| Cysteamine improves growth performance and gastric ghrelin expression in preweaning piglets. | |
| | |
MedLine Citation:
|
PMID: 22236828 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
The aim of the present study was to investigate the effect of cysteamine on growth performance of preweaning piglets and gastric expression of ghrelin mRNA in vivo and in vitro. Twelve litters of newborn piglets were allocated randomly to control and treatment groups. From 15 d of age, piglets in the control group were fed basal creep diet, whereas the treatment group received basal diet supplemented with 120 mg cysteamine per kg of diet until weaning on 35 d of age. Body weight gain, creep feed consumption, and diarrhea rates were recorded, and gastric mucosal tissues were collected for quantifying mRNA expression. To evaluate the direct effect of cysteamine on gastric ghrelin expression, primary cultures of gastric mucosal cells isolated from 35-d-old piglets were exposed to cysteamine for 20 h at 0, 1, 10, and 100 μg/mL, respectively. Dietary cysteamine increased (P < 0.05) average daily creep feed consumption and BW gain in preweaning pigs, which was accompanied by reduction in diarrhea rates. At 35 d of age, piglets treated with cysteamine showed increased (P < 0.05) ghrelin and gastrin and decreased (P < 0.05) somatostatin mRNA expression in gastric mucosa. Moreover, dietary cysteamine treatment increased serum concentration of gastrin (P < 0.05). In vitro, cysteamine significantly increased ghrelin mRNA expression in gastric mucosal cells at the concentration of 10 μg/mL. In conclusion, dietary cysteamine is effective in improving the growth performance and health condition of preweaning piglets, which is associated with its stimulatory effects on gastric ghrelin mRNA expression both in vivo and in vitro. |
| | |
Authors:
|
G Du; Z Shi; D Xia; X Wei; L Zhang; N Parvizi; R Zhao |
Related Documents
:
|
17687838 - In vivo (rat assay) assessment of nutritional improvement of peas (pisum sativum l.). 12042438 - Amino acid availability affects amino acid flux and protein metabolism in the porcine m... 15510558 - Effect of dietary crude protein and lysine on feather growth in chicks to twenty-one da... 3121568 - Self-selection by growing pigs of diets differing in lysine content. 694778 - Teratogenic potential of blighted potato concentrate in rabbits, hamsters, and miniatur... 1548978 - Total plasma cholesterol levels of rats are increased following only three sessions of ... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-12-31 |
Journal Detail:
|
Title: Domestic animal endocrinology Volume: - ISSN: 1879-0054 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2012-1-12 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8505191 Medline TA: Domest Anim Endocrinol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012 Elsevier Inc. All rights reserved. |
Affiliation:
|
Key Laboratory of Animal Physiology and Biochemistry, Ministry of Agriculture, Nanjing Agricultural University, Nanjing 210095, P. R. China; Department of Animal Science and Technology, Jinling Technology Institution, Nanjing 210038, P. R. China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Long-term health-related quality of life after decompressive hemicraniectomy in stroke patients with...
Next Document: The degradation and biocompatibility of pH-sensitive biodegradable polyurethanes for intracellular m...