Document Detail

Cystatin A protease inhibitor and cysteine proteases in human cervicovaginal fluid in term pregnancy and labor.
MedLine Citation:
PMID:  21167469     Owner:  NLM     Status:  Publisher    
OBJECTIVE:: The purpose of this study was to investigate the temporal changes in immunoreactive cystatin A and the enzymatic activity of cathepsins B, H, L, and S in human cervicovaginal fluid (CVF) in late pregnancy and spontaneous labor. STUDY DESIGN:: CVF was collected weekly (n = 95 women) from 36 weeks gestation until spontaneous term labor. Cystatin A was quantified using enzyme-linked immunosorbent assay. The enzyme activity of cathepsins B, H, L, and S was measured with fluorometric enzyme assay kits. RESULTS:: Cystatin A significantly decreased towards (P = .016, 2-way analysis of variance) and during labor (P < .001, 2-way analysis of variance). Enzymatic activity of cathepsins B, H, and S did not change with labor onset (P = .452, P = .703, P = .411, respectively, 2-way analysis of variance). CONCLUSION:: In late gestation, CVF-decreased expression of the cysteine protease inhibitor, cystatin A, is associated with labor. Although the role and contribution of cystatin A to increased extracellular matrix remodeling has yet to be elucidated, the data that were obtained are consistent with this hypothesis.
Yujing J Heng; Megan K W Di Quinzio; Michael Permezel; Gregory E Rice; Harry M Georgiou
Related Documents :
21526209 - Association of fmr1 genotypes with in vitro fertilization (ivf) outcomes based on ethni...
21129139 - Relationship of maternal weight status and weight gain rate during pregnancy to the dev...
21512119 - Fixed-time artificial insemination in replacement beef heifers after estrus synchroniza...
21485729 - Troponin i, c-reactive protein and fibrinogen levels in missed abortions.
17241959 - Sap flow estimates of stand transpiration at two slope positions in a japanese cedar fo...
3225569 - Laboratory oviposition, fecundity and egg hatching ability of colonized anopheles albim...
16532909 - Obstetricians' attitudes and opinions on sickness absence and benefits during pregnancy.
16256189 - Contribution of the oocyte to embryo quality.
4071329 - The use of piracetam in vertigo.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2010-12-15
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  -     ISSN:  1097-6868     ISO Abbreviation:  -     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2010 Mosby, Inc. All rights reserved.
Department of Obstetrics & Gynecology, University of Melbourne, Parkville, Victoria, Australia; Mercy Perinatal Research Centre, Mercy Hospital for Women, Heidelberg, Victoria, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  GCTA: a tool for genome-wide complex trait analysis.
Next Document:  Gestational diabetes mellitus alters maternal and neonatal circulating endothelial progenitor cell s...