Document Detail


Cystatin C and risk of hip fractures in older women.
MedLine Citation:
PMID:  23300153     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To test the hypothesis that older women with higher cystatin C are at increased risk of hip fracture independent of traditional risk factors including hip bone mineral density (BMD), we performed a case-cohort analysis nested in a cohort of 4709 white women attending a Year 10 (1997-1998) examination of the Study of Osteoporotic Fractures that included a random sample of 1170 women and the first 300 women with incident hip fracture occurring after Year 10 examination. Serum cystatin C and creatinine were measured in Year 10 sera. In a model adjusted for age, clinical site, body mass index, and total hip BMD, higher cystatin C was associated with an increased risk of hip fracture (p for linear trend 0.008) with women in quartile 4 having a 1.9-fold higher risk (hazard ratio [HR] 1.91; 95% confidence interval [CI], 1.24-2.95) compared with those in quartile 1 (referent group). Further adjustment for additional risk factors only slightly attenuated the association; the risk for hip fracture was 1.7-fold higher (HR 1.74; 95% CI, 1.11-2.72) in women in quartile 4 compared with those in quartile 1. In contrast, neither serum creatinine nor creatinine-based estimated glomerular filtration rate (eGFRCr ) were associated with risk of hip fracture. Older women with higher cystatin C, but not higher serum creatinine or lower eGFRCr , have an increased risk of hip fracture independent of traditional risk factors. These findings suggest that cystatin C may be a promising biomarker for identification of older adults at high risk of hip fracture.
Authors:
Kristine E Ensrud; Neeta Parimi; Jane A Cauley; Areef Ishani; Yelena Slinin; Teresa A Hillier; Brent C Taylor; Michael Steffes; Steven R Cummings;
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research     Volume:  28     ISSN:  1523-4681     ISO Abbreviation:  J. Bone Miner. Res.     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-05-22     Completed Date:  2013-12-09     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  8610640     Medline TA:  J Bone Miner Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1275-82     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 American Society for Bone and Mineral Research.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Biological Markers / blood
Creatinine / blood
Cystatin C / blood*
Female
Follow-Up Studies
Glomerular Filtration Rate
Hip Fractures / blood*,  etiology,  physiopathology
Humans
Male
Osteoporosis, Postmenopausal / blood*,  complications,  physiopathology
Risk Factors
Time Factors
Grant Support
ID/Acronym/Agency:
R01 AG005394/AG/NIA NIH HHS; R01 AG005394/AG/NIA NIH HHS; R01 AG005407/AG/NIA NIH HHS; R01 AG005407/AG/NIA NIH HHS; R01 AG027574/AG/NIA NIH HHS; R01 AG027574/AG/NIA NIH HHS; R01 AG027576/AG/NIA NIH HHS; R01 AG027576/AG/NIA NIH HHS; R01 AR035582/AR/NIAMS NIH HHS; R01 AR035583/AR/NIAMS NIH HHS; R01 AR035584/AR/NIAMS NIH HHS; R01 AR35582/AR/NIAMS NIH HHS; R01 AR35583/AR/NIAMS NIH HHS; R01 AR35584/AR/NIAMS NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/CST3 protein, human; 0/Cystatin C; AYI8EX34EU/Creatinine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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