Document Detail


Cystatin C in cerebrospinal fluid as a biomarker of ALS.
MedLine Citation:
PMID:  19444952     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Amyotrophic lateral sclerosis (ALS) is diagnosed on the basis of progressive symptoms in both the upper and lower motor neurons. Because there are no specific biomarkers for ALS, it is difficult to diagnose this disease in its early stages. Cerebrospinal fluid (CSF) samples were obtained from 14 patients in the early stages of ALS, from 13 with polyneuropathy, and from 16 with other neurological disorders. The concentration of cystatin C in the CSF was measured using a sandwich enzyme-linked immunosorbent assay (ELISA) kit. The concentration of cystatin C in the CSF was significantly lower in ALS patients than in the control subjects who were patients with polyneuropathy or other neurological diseases (patients with ALS, polyneuropathy, and other diseases exhibited 5.5 +/- 0.3, 6.7 +/- 0.4, and 6.9 +/- 0.3 mg/L cystatin C, respectively; ALS patients vs. control subjects: p = 0.014 and ALS patients vs. polyneuropathy patients: p = 0.024). Cystatin C may be a useful biomarker of ALS and can be used to distinguish between ALS and polyneuropathy.
Authors:
Sachiko Tsuji-Akimoto; Ichiro Yabe; Masaaki Niino; Seiji Kikuchi; Hidenao Sasaki
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroscience letters     Volume:  452     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-05-13     Completed Date:  2009-06-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  52-5     Citation Subset:  IM    
Affiliation:
Department of Neurology, Graduate School of Medicine, Hokkaido University, Sapporo City, Hokkaido, Japan. tujitti@jb3.so-net.ne.jp
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MeSH Terms
Descriptor/Qualifier:
Aged
Amyotrophic Lateral Sclerosis / cerebrospinal fluid*
Biological Markers / cerebrospinal fluid
Cystatin C / cerebrospinal fluid*
Enzyme-Linked Immunosorbent Assay / methods
Female
Humans
Male
Middle Aged
Nervous System Diseases / cerebrospinal fluid
Polyneuropathies / cerebrospinal fluid
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Cystatin C

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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