| Cystatin C, associated with hemorrhagic and ischemic stroke, is a strong predictor of the risk of cardiovascular events and death in Chinese. | |
| | |
MedLine Citation:
|
PMID: 17947596 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND AND PURPOSE: Cystatin C, a serum measure of renal function, has been reported as a strong predictor of risk of death and cardiovascular events in elderly people. We investigated the association between cystatin C and first-ever stroke and evaluated the predictive value of cystatin C in cardiovascular events and death from all causes based on the outcomes of a 5-year follow-up. METHODS: We recruited 293 stroke patients (199 cases of cerebral infarction, 94 cases of cerebral hemorrhage) and 894 controls. For each measure, the study population was divided into quintiles. RESULTS: Total plasma cystatin C levels were significantly higher in patients than controls. Higher cystatin C levels were directly associated with a higher risk of stroke. As compared with the first (lowest) quintile, the hazard ratios (and 95% CIs) for stroke were as follows: second quintile, 1.97 (1.07 to 3.64); third quintile, 2.71 (1.50 to 4.90); fourth quintile, 3.79 (2.12 to 6.75); fifth quintile, 6.38 (3.60 to 11.32). Follow-up of the patients and controls also showed that high cystatin C levels were associated with high prevalence of cardiovascular events or death from all causes. CONCLUSIONS: Elevated cystatin C levels were independently associated with both ischemic and hemorrhagic stroke, and cystatin C was a strong predictor for the risk of cardiovascular events and death. |
| | |
Authors:
|
Li Ni; Jiagao Lü; Ling Bo Hou; Jiang Tao Yan; Qiao Fan; Rutai Hui; Katherine Cianflone; Wei Wang; Dao Wen Wang |
Related Documents
:
|
18176296 - Antiplatelet agents for stroke prevention following transient ischemic attack. 16832006 - Healthy lifestyle and the risk of stroke in women. 19211276 - Synchronous carotid endarterectomy and off-pump coronary bypass: an updated, systematic... 16131586 - Insulin-like growth factor (igf) i, -ii, and igf binding protein-3 and risk of ischemic... 11240666 - The use of human papillomavirus typing in detection of cervical neoplasia in recife (br... 12882436 - Demographic and psychosocial correlates of physical activity among african americans. |
Publication Detail:
|
Type: Letter; Multicenter Study; Research Support, Non-U.S. Gov't Date: 2007-10-18 |
Journal Detail:
|
Title: Stroke; a journal of cerebral circulation Volume: 38 ISSN: 1524-4628 ISO Abbreviation: Stroke Publication Date: 2007 Dec |
Date Detail:
|
Created Date: 2007-11-27 Completed Date: 2008-01-02 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 0235266 Medline TA: Stroke Country: United States |
Other Details:
|
Languages: eng Pagination: 3287-8 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Brain Ischemia / diagnosis*, ethnology, mortality Cardiovascular Diseases / diagnosis*, ethnology, mortality Cerebral Hemorrhage / diagnosis*, ethnology, mortality China Cystatin C Cystatins / blood, physiology* Female Hemorrhage / diagnosis, pathology Humans Male Middle Aged Prognosis Risk Stroke / diagnosis*, ethnology, mortality |
| Chemical | |
Reg. No./Substance:
|
0/CST3 protein, human; 0/Cystatin C; 0/Cystatins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Noninvasive detection of diffuse intracranial disease.
Next Document: When the worst headache becomes the worst heartache!