| Cystatin C identifies patients with stable chronic heart failure at increased risk for adverse cardiovascular events. | |
| | |
MedLine Citation:
|
PMID: 22899766 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Renal function is a strong predictor of adverse events in heart failure. Current renal function measures are imperfect, and cystatin C (CysC) is promoted as a better marker of glomerular filtration rate. This study compares the prognostic use of CysC and derived glomerular filtration rate estimates with other measures of renal function in patients with chronic heart failure. METHODS AND RESULTS: We measured serum CysC levels in 823 patients with heart failure undergoing coronary angiography with follow-up of major adverse cardiovascular events (death, myocardial infarction, stroke). CysC levels strongly correlated with creatinine (r=0.73), blood urea nitrogen (r=0.70), and estimated glomerular filtration rate by the 4-variable modification of diet in renal disease equation (r=-0.62) (all P<0.001). However, the correlation was lower in estimated glomerular filtration rate ≥60 mL/min per 1.73 m(2). CysC-based measures significantly improved areas under the receiver operating characteristic curve for the prediction of major adverse cardiovascular events, especially in estimated glomerular filtration rate ≥60 mL/min per 1.73 m(2) (P<0.01). Net reclassification improvement was 22.2% (P<0.001) in this group. CysC remained an independent predictor of major adverse cardiovascular events (P<0.001) after adjustment for traditional risk factors and brain natriuretic peptide. CONCLUSIONS: CysC is an independent predictor of adverse events in chronic heart failure. It adds prognostic value to creatinine, particularly in patients with preserved renal function. |
| | |
Authors:
|
Matthias Dupont; Yuping Wu; Stanley L Hazen; W H Wilson Tang |
Related Documents
:
|
23515736 - Sanguineous normothermic, intermittent cardioplegia, effects on hypertrophic myocardium... 19691906 - Reliability of echocardiographic measurements of left cardiac structures in healthy chi... 9331556 - A quantitative description of dynamic left ventricular geometry in anaesthetized rats u... 2353656 - Comparison with radionuclide angiography of two new geometric and four nongeometric mod... 11253736 - Fibrinolytic parameters and insulin resistance in young survivors of myocardial infarct... 11025346 - Update on the management of acute coronary syndromes. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2012-08-16 |
Journal Detail:
|
Title: Circulation. Heart failure Volume: 5 ISSN: 1941-3297 ISO Abbreviation: Circ Heart Fail Publication Date: 2012 Sep |
Date Detail:
|
Created Date: 2012-09-19 Completed Date: 2012-12-03 Revised Date: 2013-04-16 |
Medline Journal Info:
|
Nlm Unique ID: 101479941 Medline TA: Circ Heart Fail Country: United States |
Other Details:
|
Languages: eng Pagination: 602-9 Citation Subset: IM |
Affiliation:
|
Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH, USA. |
| Data Bank Information | |
Bank Name/Acc. No.:
|
ClinicalTrials.gov/NCT00590200 |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Aged, 80 and over Biological Markers / blood Cardiovascular Diseases / blood, diagnosis*, mortality, physiopathology Chi-Square Distribution Chronic Disease Coronary Angiography Cystatin C / blood* Female Glomerular Filtration Rate Heart Failure / blood, diagnosis*, mortality, physiopathology Humans Kaplan-Meier Estimate Kidney / metabolism, physiopathology* Male Middle Aged Models, Biological Multivariate Analysis Myocardial Infarction / blood, diagnosis, mortality, physiopathology Natriuretic Peptide, Brain / blood Ohio Predictive Value of Tests Prognosis Proportional Hazards Models Risk Assessment Risk Factors Stroke / blood, diagnosis, mortality, physiopathology |
| Grant Support | |
ID/Acronym/Agency:
|
1P20HL113452-01/HL/NHLBI NIH HHS; 1R01HL103931-02/HL/NHLBI NIH HHS; 5P01HL103453/HL/NHLBI NIH HHS; P01 HL076491/HL/NHLBI NIH HHS; P01 HL098055/HL/NHLBI NIH HHS; P01 HL103453/HL/NHLBI NIH HHS; P01HL076491-055328/HL/NHLBI NIH HHS; P01HL098055-01/HL/NHLBI NIH HHS; P20 HL113452/HL/NHLBI NIH HHS; R01 HL103866/HL/NHLBI NIH HHS; R01 HL103931/HL/NHLBI NIH HHS; R01HL103866/HL/NHLBI NIH HHS; UL1 TR000439/TR/NCATS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers; 0/CST3 protein, human; 0/Cystatin C; 114471-18-0/Natriuretic Peptide, Brain |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Molecular weight-dependent genetic information transfer with disulfide-linked polyethylenimine-based...
Next Document: Ventilatory Power: A Novel Index that Enhances Prognostic Assessment of Patients with Heart Failure.