| Cystatin C and Baseline Renal Function Among HIV-infected Persons in the SUN Study. | |
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MedLine Citation:
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PMID: 21480819 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background: In the cART era, renal dysfunction remains common. Methods: The Study to Understand the Natural History of HIV/AIDS in the Era of Effective Therapy (SUN) (ClinicalTrials.gov number, NCT00146419) is a prospective observational cohort study of HIV-infected adults. At baseline, comprehensive data were collected, including cystatin C and measures of renal function. Univariate and multivariate regression analyses were performed to identify factors associated with baseline renal dysfunction (eGFR < 90mL/min/1.73m2 calculated using the simplified Modification of Diet in Renal Disease equation) and elevated cystatin C (> 1.0mg/L) in a cross-sectional analysis. Results: Among 670 subjects with complete data (mean age 41 years, mean CD4 cell count 530 cells/mm3, 79% prescribed cART), the mean eGFR was 96.8 mL/min/1.73m2. Forty percent of subjects had renal dysfunction; 3.3% had chronic renal failure (eGFR < 60mL/min/1.73m2). Elevated cystatin C was present in 18% of subjects. In multivariate analysis, renal dysfunction was associated with older age, non-Hispanic white race/ethnicity, higher BMI, hypertension, higher cystatin C levels, and current prescription of ritonavir. Factors associated with elevated cystatin C included hepatitis C co-infection, hypertension, current smoking, older age, current tenofovir use, detectable plasma HIV RNA, and elevated microalbuminuria. Conclusions: The prevalence of chronic kidney disease (CKD) was low in this contemporary HIV cohort. However, mild to moderate renal dysfunction was common despite the widespread use of cART. |
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Authors:
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Turner Overton; Pragna Patel; Kristin Mondy; Tim Bush; Lois Conley; Frank Rhame; Erna Milunka Kojic; John Hammer; Keith Henry; John Brooks |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-12 |
Journal Detail:
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Title: AIDS research and human retroviruses Volume: - ISSN: 1931-8405 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8709376 Medline TA: AIDS Res Hum Retroviruses Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Washington University, St Louis, Missouri, United States; toverton@DOM.wustl.edu. |
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