Document Detail

Cystatin A and B in the development of human squamous epithelia.
MedLine Citation:
PMID:  2113341     Owner:  NLM     Status:  MEDLINE    
The expression of cystatin A (Acid cysteine proteinase inhibitor) and B (Neutral cysteine proteinase inhibitor) during human embryogenesis was studied immunohistochemically by using the PAP-complex method. Both inhibitors were visible first in the developing mucosal tissue at the age of about 9 weeks. In the fetal epidermis (periderm), cystatin B was demonstrated at the age of 11 weeks and cystatin A at 12 weeks. In these young fetuses, the staining was visible in the basal cells, whereas in fetuses older than 17 weeks the staining of both inhibitors diminished in the basal cells. In the skin of 17 to 25 weeks old fetuses, the epidermal staining of cystatin B become weaker than that of cystatin A, and at the age of about 26 weeks, cystatin B disappeared totally. At this stage, cystatin A was localized in the cytoplasm of the middle to upper cell layers of the epidermis. In the squamous epithelia of the mucosal tissues, the staining of the both inhibitors reached their maximal intensity when the fetuses were about 16 weeks old. At the mature fetuses, infants as well as adults, both cystatin A and B seemed to be present in wet squamous epithelia while in the epidermis only cystatin A was expressed.
H Pernu; O Räsänen; T Salo; A Rinne; R Herva; M Järvinen
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta histochemica     Volume:  88     ISSN:  0065-1281     ISO Abbreviation:  Acta Histochem.     Publication Date:  1990  
Date Detail:
Created Date:  1990-07-24     Completed Date:  1990-07-24     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370320     Medline TA:  Acta Histochem     Country:  GERMANY, EAST    
Other Details:
Languages:  eng     Pagination:  53-7     Citation Subset:  IM    
Department of Oral Surgery, University of Oulu, Finland.
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MeSH Terms
Cystatin B
Cystatins / analysis*
Embryo, Mammalian
Embryonic and Fetal Development
Epidermis / cytology,  embryology*,  growth & development
Mouth Mucosa / cytology,  embryology*,  growth & development
Reg. No./Substance:
0/CSTB protein, human; 0/Cystatins; 88844-95-5/Cystatin B

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