| Cystathionine gamma-synthase and threonine synthase operate in concert to regulate carbon flow towards methionine in plants. | |
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MedLine Citation:
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PMID: 11950610 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The sulfur-containing amino acid methionine is a nutritionally important essential amino acid and is the precursor of several metabolites that regulate plant growth and responses to the environment. Methionine production is largely regulated by cystathionine gamma-synthase, the first specific enzyme for its synthesis. This enzyme competes in a complex manner with threonine synthase, the last enzyme in threonine biosynthesis, for their common substrate O-phosphohomoserine. New genetic and molecular data suggest that methionine synthesis and catabolism are coordinately regulated by novel post-transcriptional and post-translational mechanisms that are associated with a regulatory part within the N-terminal part of cystathionine gamma-synthase. |
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Authors:
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Rachel Amir; Yael Hacham; Gad Galili |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Trends in plant science Volume: 7 ISSN: 1360-1385 ISO Abbreviation: Trends Plant Sci. Publication Date: 2002 Apr |
Date Detail:
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Created Date: 2002-04-12 Completed Date: 2002-06-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9890299 Medline TA: Trends Plant Sci Country: England |
Other Details:
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Languages: eng Pagination: 153-6 Citation Subset: IM |
Affiliation:
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Plant Science Laboratory, Migal Galilee Technological Center, PO Box 90000, Rosh Pina 12100, Israel. rachel@migal.org.il |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aspartic Acid
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metabolism Binding, Competitive Carbon / metabolism* Carbon-Oxygen Lyases / genetics, metabolism* Homoserine / analogs & derivatives*, metabolism Methionine / metabolism* Plants / genetics*, growth & development, metabolism Protein Processing, Post-Translational RNA Processing, Post-Transcriptional |
| Chemical | |
Reg. No./Substance:
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4210-66-6/O-phosphohomoserine; 498-19-1/Homoserine; 56-84-8/Aspartic Acid; 63-68-3/Methionine; 7440-44-0/Carbon; EC 4.2.-/Carbon-Oxygen Lyases; EC 4.2.99.2/threonine synthase; EC 4.2.99.9/O-succinylhomoserine (thiol)-lyase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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