| Cynomorium songaricum extracts functionally modulate transporters of gamma-aminobutyric acid and monoamine. | |
| | |
MedLine Citation:
|
PMID: 20084455 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Cynomorium songaricum Rupr. (SY) is a central nervous system-oriented herb material that has actions of anti-dementia, anti-epilepsy, and anti-stress. It is unclear whether SY would be biologically active in functionally regulating neurotransmitter transporters. Here, we assessed these potential actions using Chinese hamster ovary cells expressing gamma-aminobutyric acid (GABA) transporter (GAT-1), dopamine transporter (DAT), norepinephrine transporter (NET), or serotonin transporter (SERT) (i.e. G1, D8, N1, or S6 cells, respectively). It was shown that SY extracts, such as SYw, SYa, SYp, SYc, SYe, and SYb (SY water, ethanol, petroleum ether, chloroform, ethyl acetate, and n-butyl alcohol extract, respectively) increased dopamine/norepinephrine (DA/NE) uptake by corresponding D8/N1 cells and decreased gamma-aminobutyric acid/serotoin (GABA/5HT) uptake by corresponding G1/S6 cells; wherein, the potency or efficacy of SYc for up-regulating DA/NE uptake and that of SYb for inhibiting GABA/5HT uptake were relatively stronger. Additionally, GABA/5H-uptake inhibition by SY extracts were also seen in cortical synaptosomes, and DA/NE-uptake enhancement by SYc was dependent on the activity of DAT and NET. Thus, SY extracts especially SYc and SYb are novel neurotransmitter-transporter modulators functioning as DAT/NET activators and/or GAT-1/SERT inhibitors. |
| | |
Authors:
|
Gang Zhao; Jie Wang; Guo-Wei Qin; Li-He Guo |
Related Documents
:
|
5961355 - Amino acid and sugar transport in rabbit ileum. 1025575 - Regulation of transport in mammalian cell culture. 15848195 - Functional regulation of na+-dependent neutral amino acid transporter asct2 by s-nitros... 8488475 - Regulation of small intestinal glutamine transport by epidermal growth factor. 1716905 - Biogenic amines and metabolites in spinal cord of patients with parkinson's disease and... 10740865 - Amino acid analysis by capillary electrophoresis electrospray ionization mass spectrome... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Neurochemical research Volume: 35 ISSN: 1573-6903 ISO Abbreviation: Neurochem. Res. Publication Date: 2010 Apr |
Date Detail:
|
Created Date: 2010-03-18 Completed Date: 2010-08-02 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7613461 Medline TA: Neurochem Res Country: United States |
Other Details:
|
Languages: eng Pagination: 666-76 Citation Subset: IM |
Affiliation:
|
Cell Star Bio-Technologies Co., Limited, Shanghai, People's Republic of China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Brain / drug effects, metabolism CHO Cells Cricetinae Cricetulus Cynomorium / chemistry* Dopamine Plasma Membrane Transport Proteins / metabolism* GABA Plasma Membrane Transport Proteins / metabolism* Norepinephrine Plasma Membrane Transport Proteins / metabolism* Plant Extracts / pharmacology* Serotonin / metabolism Serotonin Plasma Membrane Transport Proteins / metabolism* Synaptosomes / drug effects, metabolism gamma-Aminobutyric Acid / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Dopamine Plasma Membrane Transport Proteins; 0/GABA Plasma Membrane Transport Proteins; 0/Norepinephrine Plasma Membrane Transport Proteins; 0/Plant Extracts; 0/Serotonin Plasma Membrane Transport Proteins; 50-67-9/Serotonin; 56-12-2/gamma-Aminobutyric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Centromere targeting of alien CENH3s in Arabidopsis and tobacco cells.
Next Document: Microwave-assisted synthesis of a novel class of imidazolylthiazolidin-4-ones and evaluation of its ...