Document Detail


Cymatherelactone and cymatherols A-C, polycyclic oxylipins from the marine brown alga Cymathere triplicata.
MedLine Citation:
PMID:  22071135     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An investigation of the oxylipin chemistry of the temperate brown alga Cymathere triplicata led to the isolation of several secondary metabolites, cymatherelactone (1) and cymatherols A-C (2-4), the latter as their methyl ester derivatives (5-7), which contained cyclopentyl, cyclopropyl, epoxide and lactone rings. Their structures were elucidated using a combination of spectroscopic techniques and synthetic chemistry. Cymatherelactone (1), as well as R- and S-Mosher's esters of its seco acid, exhibited moderate sodium channel blocking activity.
Authors:
Hyukjae Choi; Philip J Proteau; Tara Byrum; Alban R Pereira; William H Gerwick
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-11-07
Journal Detail:
Title:  Phytochemistry     Volume:  73     ISSN:  1873-3700     ISO Abbreviation:  Phytochemistry     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-12-27     Completed Date:  2012-02-24     Revised Date:  2012-06-18    
Medline Journal Info:
Nlm Unique ID:  0151434     Medline TA:  Phytochemistry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  134-41     Citation Subset:  IM    
Copyright Information:
Copyright © 2011. Published by Elsevier Ltd.
Affiliation:
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093-0212, United States.
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MeSH Terms
Descriptor/Qualifier:
Marine Biology
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Oxylipins / chemistry,  isolation & purification*,  pharmacology
Phaeophyta / chemistry*
Sodium Channel Blockers / chemistry,  isolation & purification*,  pharmacology
Grant Support
ID/Acronym/Agency:
NS053398/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Oxylipins; 0/Sodium Channel Blockers; 0/cymatherelactone; 0/cymatherol A; 0/cymatherol B; 0/cymatherol C
Comments/Corrections
Erratum In:
Phytochemistry. 2012 Jun;78:197
Note: Pereira, Alban R [added]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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