Document Detail

Cylindrospermopsin: occurrence, methods of detection and toxicology.
MedLine Citation:
PMID:  23082903     Owner:  NLM     Status:  Publisher    
Cyanobacteria are aquatic microorganisms that pose a great threat to aquatic ecosystems by the production of dense blooms, but most importantly by the production of secondary metabolites, namely the cyanotoxins. One of these is cylindrospermopsin (CYN) a hepatotoxic polyketide derived alkaloid with well-known associated cases of animal mortalities and human morbidity. First described as being associated with liver damage, this toxin is now considered a cytotoxic and a genotoxic toxin, due to its effects in other organs and in DNA. Its occurrence has been reported so far in eight different cyanobacteria species and in several water samples from four of the five continents. With a guideline value of 1 μg/L, CYN is now considered the second most studied cyanotoxin worldwide. It is important to review the information regarding the findings made until now about this cyanotoxin 30 years since its first report. © 2012The Authors Journal of Applied Microbiology © 2012 The Society for Applied Microbiology.
Cristiana Moreira; Joana Azevedo; Agostinho Antunes; Vitor Vasconcelos
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-22
Journal Detail:
Title:  Journal of applied microbiology     Volume:  -     ISSN:  1365-2672     ISO Abbreviation:  J. Appl. Microbiol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9706280     Medline TA:  J Appl Microbiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012The Authors Journal of Applied Microbiology © 2012 The Society for Applied Microbiology.
Laboratory of Ecotoxicology, Genomics and Evolution, CIMAR/CIIMAR, Porto University, Rua dos Bragas, 289 4050-123, Porto, Portugal; Departamento de Biologia, Faculdade de Ciências, Universidade do Porto, Rua do Campo Alegre, 4169-007, Porto, Portugal.
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