Document Detail


Cyclotron production of NCA 99mTc and 99Mo. An alternative non-reactor supply source of instant 99mTc and 99Mo----99mTc generators.
MedLine Citation:
PMID:  1663097     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The direct production of no-carrier-added (NCA) 6.02 h 99mTc and of 66 h 99mMo using proton beams of natural Mo targets was investigated. The major objective of this work was to evaluate the potential of utilizing high-intensity proton accelerators as a supply source of 99mTc and 99Mo for use in diagnostic nuclear medicine. The excitation functions for the production of the directly-made 99mTc via the 100Mo(p, 2n)99mTc (Q = -7.85 MeV) reaction, and of its parent 99Mo via the 100Mo(p, pn) 99Mo (Q = -8.30 MeV) and 100Mo(p, 2p)99mNb(15 s)----99Mo (Q = -11.14 MeV) reactions, were measured in the 68-8 MeV energy range. Single and cumulative yields for 99mTc and 99Mo, and for other Tc, Mo, Zr, Nb and Y radiocontaminants were also determined. The prospects of integrating the use of enriched 100Mo targets with high-intensity, dual beam, H- accelerators was analyzed. The potential of this combined method to replace or complement the current reactor-based supply sources of 99Mo----99mTc generators, is also discussed. Finally, a brief analysis is made on the potential use of this combined technology to support the anticipated expansion of nuclear medicine in developing nations.
Authors:
M C Lagunas-Solar; P M Kiefer; O F Carvacho; C A Lagunas; Y P Cha
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes     Volume:  42     ISSN:  0883-2889     ISO Abbreviation:  Int J Rad Appl Instrum A     Publication Date:  1991  
Date Detail:
Created Date:  1992-02-27     Completed Date:  1992-02-27     Revised Date:  2009-06-04    
Medline Journal Info:
Nlm Unique ID:  8611097     Medline TA:  Int J Rad Appl Instrum A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  643-57     Citation Subset:  IM    
Affiliation:
Radioisotope Program, Crocker Nuclear Laboratory University of California, Davis 95616.
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MeSH Terms
Descriptor/Qualifier:
Molybdenum*
Particle Accelerators*
Radioisotopes
Radionuclide Generators*
Technetium*
Chemical
Reg. No./Substance:
0/Radioisotopes; 7439-98-7/Molybdenum; 7440-26-8/Technetium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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